GABAergic interneurons in the neocortex: from cellular properties to circuits

R Tremblay, S Lee, B Rudy - Neuron, 2016 - cell.com
Cortical networks are composed of glutamatergic excitatory projection neurons and local
GABAergic inhibitory interneurons that gate signal flow and sculpt network dynamics …

Network abnormalities and interneuron dysfunction in Alzheimer disease

JJ Palop, L Mucke - Nature Reviews Neuroscience, 2016 - nature.com
The function of neural circuits and networks can be controlled, in part, by modulating the
synchrony of their components' activities. Network hypersynchrony and altered oscillatory …

Ketamine triggers a switch in excitatory neuronal activity across neocortex

J Cichon, AZ Wasilczuk, LL Looger, D Contreras… - Nature …, 2023 - nature.com
The brain can become transiently disconnected from the environment while maintaining
vivid, internally generated experiences. This so-called 'dissociated state'can occur in …

Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning

G Buzsáki - Hippocampus, 2015 - Wiley Online Library
Sharp wave ripples (SPW‐Rs) represent the most synchronous population pattern in the
mammalian brain. Their excitatory output affects a wide area of the cortex and several …

Transcriptional architecture of synaptic communication delineates GABAergic neuron identity

A Paul, M Crow, R Raudales, M He, J Gillis, ZJ Huang - Cell, 2017 - cell.com
Understanding the organizational logic of neural circuits requires deciphering the biological
basis of neuronal diversity and identity, but there is no consensus on how neuron types …

Hippocampal GABAergic inhibitory interneurons

KA Pelkey, R Chittajallu, MT Craig… - Physiological …, 2017 - journals.physiology.org
In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

The role of the medial prefrontal cortex in the conditioning and extinction of fear

TF Giustino, S Maren - Frontiers in behavioral neuroscience, 2015 - frontiersin.org
Once acquired, a fearful memory can persist for a lifetime. Although learned fear can be
extinguished, extinction memories are fragile. The resilience of fear memories to extinction …

Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders

R Gao, P Penzes - Current molecular medicine, 2015 - ingentaconnect.com
Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlap** behavioral phenotypes, which suggests …

Mechanisms of gamma oscillations

G Buzsáki, XJ Wang - Annual review of neuroscience, 2012 - annualreviews.org
Gamma rhythms are commonly observed in many brain regions during both waking and
sleep states, yet their functions and mechanisms remain a matter of debate. Here we review …

Alterations in cortical interneurons and cognitive function in schizophrenia

SJ Dienel, DA Lewis - Neurobiology of disease, 2019 - Elsevier
Certain clinical features of schizophrenia, such as working memory disturbances, appear to
emerge from altered gamma oscillatory activity in the prefrontal cortex (PFC). Given the …