GABAergic interneurons in the neocortex: from cellular properties to circuits
Cortical networks are composed of glutamatergic excitatory projection neurons and local
GABAergic inhibitory interneurons that gate signal flow and sculpt network dynamics …
GABAergic inhibitory interneurons that gate signal flow and sculpt network dynamics …
Network abnormalities and interneuron dysfunction in Alzheimer disease
The function of neural circuits and networks can be controlled, in part, by modulating the
synchrony of their components' activities. Network hypersynchrony and altered oscillatory …
synchrony of their components' activities. Network hypersynchrony and altered oscillatory …
Ketamine triggers a switch in excitatory neuronal activity across neocortex
The brain can become transiently disconnected from the environment while maintaining
vivid, internally generated experiences. This so-called 'dissociated state'can occur in …
vivid, internally generated experiences. This so-called 'dissociated state'can occur in …
Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning
G Buzsáki - Hippocampus, 2015 - Wiley Online Library
Sharp wave ripples (SPW‐Rs) represent the most synchronous population pattern in the
mammalian brain. Their excitatory output affects a wide area of the cortex and several …
mammalian brain. Their excitatory output affects a wide area of the cortex and several …
Transcriptional architecture of synaptic communication delineates GABAergic neuron identity
Understanding the organizational logic of neural circuits requires deciphering the biological
basis of neuronal diversity and identity, but there is no consensus on how neuron types …
basis of neuronal diversity and identity, but there is no consensus on how neuron types …
Hippocampal GABAergic inhibitory interneurons
KA Pelkey, R Chittajallu, MT Craig… - Physiological …, 2017 - journals.physiology.org
In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …
of the total neuronal population; however, their remarkable anatomical and physiological …
The role of the medial prefrontal cortex in the conditioning and extinction of fear
Once acquired, a fearful memory can persist for a lifetime. Although learned fear can be
extinguished, extinction memories are fragile. The resilience of fear memories to extinction …
extinguished, extinction memories are fragile. The resilience of fear memories to extinction …
Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders
R Gao, P Penzes - Current molecular medicine, 2015 - ingentaconnect.com
Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlap** behavioral phenotypes, which suggests …
complex genetic architectures but overlap** behavioral phenotypes, which suggests …
Mechanisms of gamma oscillations
Gamma rhythms are commonly observed in many brain regions during both waking and
sleep states, yet their functions and mechanisms remain a matter of debate. Here we review …
sleep states, yet their functions and mechanisms remain a matter of debate. Here we review …
Alterations in cortical interneurons and cognitive function in schizophrenia
Certain clinical features of schizophrenia, such as working memory disturbances, appear to
emerge from altered gamma oscillatory activity in the prefrontal cortex (PFC). Given the …
emerge from altered gamma oscillatory activity in the prefrontal cortex (PFC). Given the …