[HTML][HTML] Beyond Inflammation: Role of Pyroptosis Pathway Activation by Gram-Negative Bacteria and Their Outer Membrane Vesicles (OMVs) in the Interaction with …

SC Resta, F Guerra, A Talà, C Bucci, P Alifano - Cells, 2024 - mdpi.com
Pyroptosis is a gasdermin-mediated pro-inflammatory programmed cell death that, during
microbial infections, aims to restrict the spreading of bacteria. Nevertheless, excessive …

[HTML][HTML] Mitochondrial quality control processes at the crossroads of cell death and survival: Mechanisms and signaling pathways

E Marzetti, R Calvani, F Landi… - International Journal of …, 2024 - mdpi.com
Biological aging results from an accumulation of damage in the face of reduced resilience.
One major driver of aging is cell senescence, a state in which cells remain viable but lose …

Defects of mitochondria-lysosomes communication induce secretion of mitochondria-derived vesicles and drive chemoresistance in ovarian cancer cells

S Gagliardi, M Mitruccio, R Di Corato… - Cell Communication and …, 2024 - Springer
Background Among the mechanisms of mitochondrial quality control (MQC), generation of
mitochondria-derived vesicles (MDVs) is a process to avoid complete failure of mitochondria …

Neisseria meningitidis activates pyroptotic pathways in a mouse model of meningitis: role of a two-partner secretion system

C Pagliuca, R Colicchio, SC Resta, A Talà… - Frontiers in Cellular …, 2024 - frontiersin.org
There is evidence that in infected cells in vitro the meningococcal HrpA/HrpB two-partner
secretion system (TPS) mediates the exit of bacteria from the internalization vacuole and the …

[HTML][HTML] A comprehensive review on probiotics and their use in aquaculture: Biological control, efficacy, and safety through the genomics and wet methods

M Calcagnile, SM Tredici, P Alifano - Heliyon, 2024 - cell.com
Probiotics, defined as viable microorganisms that enhance host health when consumed
through the diet, exert their effects through mechanisms such as strengthening the immune …

Mitochondria-Derived Vesicles, Sterile Inflammation, and Pyroptosis in Liver Cancer: Partners in Crime or Innocent Bystanders?

F Guerra, FR Ponziani, F Cardone, C Bucci… - International Journal of …, 2024 - mdpi.com
Alterations in cellular signaling, chronic inflammation, and tissue remodeling contribute to
hepatocellular carcinoma (HCC) development. The release of damage-associated …