Genomic imprinting and parent-of-origin effects on complex traits
Parent-of-origin effects occur when the phenotypic effect of an allele depends on whether it
is inherited from the mother or the father. Several phenomena can cause parent-of-origin …
is inherited from the mother or the father. Several phenomena can cause parent-of-origin …
[KIRJA][B] Using heterogeneous stocks for fine-map** genetically complex traits
LC Solberg Woods, AA Palmer - 2019 - Springer
In this chapter we will review both the rationale and experimental design for using
Heterogeneous Stock (HS) populations for fine-map** of complex traits in mice and rats …
Heterogeneous Stock (HS) populations for fine-map** of complex traits in mice and rats …
Effects of high‐fat diet and body mass on bone morphology and mechanical properties in 1100 advanced intercross mice
Obesity is generally protective against osteoporosis and bone fracture. However, recent
studies indicate that the influence of obesity on the skeleton is complex and can be …
studies indicate that the influence of obesity on the skeleton is complex and can be …
[HTML][HTML] Reducing insulin via conditional partial gene ablation in adults reverses diet-induced weight gain
Excess circulating insulin is associated with obesity in humans and in animal models.
However, the physiologic causality of hyperinsulinemia in adult obesity has rightfully been …
However, the physiologic causality of hyperinsulinemia in adult obesity has rightfully been …
QTL map** in outbred populations: successes and challenges
LC Solberg Woods - Physiological genomics, 2014 - journals.physiology.org
Quantitative trait locus (QTL) map** in animal populations has been a successful strategy
for identifying genomic regions that play a role in complex diseases and traits. When …
for identifying genomic regions that play a role in complex diseases and traits. When …
Genetic, epigenetic, and environmental mechanisms govern allele-specific gene expression
CLS Pierre, JF Macias-Velasco, JP Wayhart… - Genome …, 2022 - genome.cshlp.org
Allele-specific expression (ASE) is a phenomenon in which one allele is preferentially
expressed over the other. Genetic and epigenetic factors cause ASE by altering the final …
expressed over the other. Genetic and epigenetic factors cause ASE by altering the final …
Parent-of-origin effects propagate through networks to shape metabolic traits
JF Macias-Velasco, CL St Pierre, JP Wayhart, L Yin… - Elife, 2022 - elifesciences.org
Parent-of-origin effects are unexpectedly common in complex traits, including metabolic and
neurological traits. Parent-of-origin effects can be modified by the environment, but the …
neurological traits. Parent-of-origin effects can be modified by the environment, but the …
Digit regeneration is expedited in LG/J healer mice compared to SM/J non-healer mice
Limb loss resulting from disease or trauma affects an estimated 185,000 Americans
annually, significantly reducing their quality of life. Consequently, successful attempts to …
annually, significantly reducing their quality of life. Consequently, successful attempts to …
Genetic effects at pleiotropic loci are context-dependent with consequences for the maintenance of genetic variation in populations
Context-dependent genetic effects, including genotype-by-environment and genotype-by-
sex interactions, are a potential mechanism by which genetic variation of complex traits is …
sex interactions, are a potential mechanism by which genetic variation of complex traits is …
T2DM: why epigenetics?
D Fradin, P Bougneres - Journal of nutrition and metabolism, 2011 - Wiley Online Library
Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder influenced by interactions between
genetic and environmental factors. Epigenetics conveys specific environmental influences …
genetic and environmental factors. Epigenetics conveys specific environmental influences …