Background: The Religious Orders Study and Rush Memory and Aging Project are both
ongoing longitudinal clinical-pathologic cohort studies of aging and Alzheimer's disease …

Hypertension is a highly prevalent condition with numerous health risks, and the incidence
of hypertension is greatest among older adults. Traditional discussions of hypertension have …

Alzheimer's disease (AD) is the most common cause of dementia worldwide, but the
molecular and cellular mechanisms underlying cognitive impairment remain poorly …

Altered microglial states affect neuroinflammation, neurodegeneration, and disease but
remain poorly understood. Here, we report 194,000 single-nucleus microglial transcriptomes …

Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …

Alzheimer's disease is the leading cause of dementia worldwide, but the cellular pathways
that underlie its pathological progression across brain regions remain poorly understood …

Cerebrovascular dysregulation is a hallmark of Alzheimer's disease (AD), but the changes
that occur in specific cell types have not been fully characterized. Here, we profile single …

Recent work has identified dozens of non-coding loci for Alzheimer's disease (AD) risk, but
their mechanisms and AD transcriptional regulatory circuitry are poorly understood. Here …

Persistent DNA double-strand breaks (DSBs) in neurons are an early pathological hallmark
of neurodegenerative diseases including Alzheimer's disease (AD), with the potential to …

Alzheimer's disease is a pervasive neurodegenerative disorder, the molecular complexity of
which remains poorly understood. Here, we analysed 80,660 single-nucleus transcriptomes …