Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by
progressive degeneration of motor neurons leading to skeletal muscle denervation. Earlier …

Neocortical pyramidal neurons with somata in layers 5 and 6 are among the most visually
striking and enigmatic neurons in the brain. These deep-layer pyramidal neurons (DLPNs) …

Oligodendrocyte loss in neurological disease leaves axons vulnerable to damage and
degeneration, and activity-dependent myelination may represent an endogenous …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder
characterized by the loss of both upper and lower motor neurons, resulting in muscle …

Amyotrophic lateral sclerosis is a devastating neurodegenerative disease that, at present,
has no effective cure. Evidence of increased circulating glutamate and hyperexcitability of …

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disorder. While there
are five FDA-approved drugs for treating this disease, each has only modest benefits. To …

Recent evidence has supported the hypothesis that amyotrophic lateral sclerosis (ALS) is a
multi-step disease, as the onset of symptoms occurs after sequential exposure to a defined …

Dysregulated neuronal excitability is a hallmark of amyotrophic lateral sclerosis (ALS). We
sought to investigate how functional changes to the axon initial segment (AIS), the site of …

Gene mutations causing cytoplasmic mislocalization of the RNA-binding protein FUS lead to
severe forms of amyotrophic lateral sclerosis (ALS). Cytoplasmic accumulation of FUS is …

Amyotrophic lateral sclerosis (ALS) is an aggressive and uniformly fatal degenerative
disease of the motor nervous system. In order to understand underlying disease …