The failure of animal models to predict therapeutic responses in humans is a major problem
that also brings into question their use for basic research. Organ-on-a-chip (organ chip) …

Biomedical research is undergoing a paradigm shift towards approaches centred on human
disease models owing to the notoriously high failure rates of the current drug development …

Tissue/organ shortage is a major medical challenge due to donor scarcity and patient
immune rejections. Furthermore, it is difficult to predict or mimic the human disease condition …

Recent advances in biomaterials, microfabrication, microfluidics, and cell biology have led to
the development of organ-on-a-chip devices that can reproduce key functions of various …

Self‐organized microvascular networks (MVNs) have become key to the development of
many microphysiological models. However, the self‐organizing nature of this process …

Microfluidics opened the possibility to model the physiological environment by controlling
fluids flows, and therefore nutrients supply. It allows to integrate external stimuli such as …

The necessity of disease models for bone/cartilage related disorders is well-recognized, but
the barrier between ex-vivo cell culture, animal models and the real human body has been …

In vitro models of the human blood–brain barrier (BBB) are increasingly used to develop
therapeutics that can cross the BBB for treating diseases of the central nervous system. Here …

Traumatic brain injury causes inflammation and glial scarring that impede brain tissue
repair, so stimulating angiogenesis and recovery of brain function remain challenging. Here …

Physiologically, brain tumors interact with surrounding vascular and glial cells, and change
their responses to survive in brain tissue‐specific microenvironments. A major difficulty in …