Intervertebral disc (IVD) degeneration is a common finding on spine imaging that increases
in prevalence with age. IVD degeneration is a frequent cause of low back pain, which is a …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal
neurodegenerative disorders that are thought to exist on a clinical and pathological …

Frontotemporal dementia (FTD) refers to a group of progressive neurodegenerative
disorders with different pathological signatures, genetic variability and complex disease …

Progranulin (PGRN), encoded by the GRN gene in humans, is a secreted growth factor
implicated in a multitude of processes ranging from regulation of inflammation to wound …

Intervertebral disc degeneration (IVDD) is a chronic, expensive, and high-incidence
musculoskeletal disorder largely responsible for back/neck and radicular-related pain. It is …

Review on the role of progranulin in immunity, infection, and inflammation, and its
therapeutic potential in treating inflammatory conditions. PGRN, a pleiotrophic growth factor …

Progranulin, a secreted glycoprotein, is encoded in humans by the single GRN gene.
Progranulin consists of seven and a half, tandemly repeated, non-identical copies of the 12 …

Loss-of-function mutations in the progranulin gene are a common cause of familial
frontotemporal dementia (FTD). The purpose of this review is to summarize the role of …

Purpose Spinal cord injury (SCI) often results in significant and catastrophic dysfunction and
disability and imposes a huge economic burden on society. This study aimed to determine …

Progranulin (PGRN) is predominantly expressed by microglia in the brain, and genetic and
experimental evidence suggests a critical role in Alzheimer's disease (AD). We asked …