CD36 as a gatekeeper of myocardial lipid metabolism and therapeutic target for metabolic disease
JFC Glatz, LC Heather… - Physiological reviews, 2024 - journals.physiology.org
The multifunctional membrane glycoprotein CD36 is expressed in different types of cells and
plays a key regulatory role in cellular lipid metabolism, especially in cardiac muscle. CD36 …
plays a key regulatory role in cellular lipid metabolism, especially in cardiac muscle. CD36 …
Nanoparticle entry into cells; the cell biology weak link
Nanoparticles (NP) are attractive options for the therapeutic delivery of active
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …
Hypoxia-induced macropinocytosis represents a metabolic route for liver cancer
MS Zhang, JD Cui, D Lee, VWH Yuen… - Nature …, 2022 - nature.com
Hepatocellular carcinoma (HCC) invariably exhibits inadequate O2 (hypoxia) and nutrient
supply. Hypoxia-inducible factor (HIF) mediates cascades of molecular events that enable …
supply. Hypoxia-inducible factor (HIF) mediates cascades of molecular events that enable …
Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system
In response to different types and intensities of mechanical force, cells modulate their
physical properties and adapt their plasma membrane (PM). Caveolae are PM nano …
physical properties and adapt their plasma membrane (PM). Caveolae are PM nano …
Caveolae: Mechanosensing and mechanotransduction devices linking membrane trafficking to mechanoadaptation
MA Del Pozo, FN Lolo, A Echarri - Current opinion in cell biology, 2021 - Elsevier
Mechanical forces (extracellular matrix stiffness, vascular shear stress, and muscle
stretching) reaching the plasma membrane (PM) determine cell behavior. Caveolae are PM …
stretching) reaching the plasma membrane (PM) determine cell behavior. Caveolae are PM …
Interplay between lipid metabolism, lipid droplets, and DNA virus infections
MA Farías, B Diethelm-Varela, AJ Navarro, AM Kalergis… - Cells, 2022 - mdpi.com
Lipid droplets (LDs) are cellular organelles rich in neutral lipids such as triglycerides and
cholesterol esters that are coated by a phospholipid monolayer and associated proteins …
cholesterol esters that are coated by a phospholipid monolayer and associated proteins …
Energy and dynamics of caveolae trafficking
Caveolae are 70–100 nm diameter plasma membrane invaginations found in abundance in
adipocytes, endothelial cells, myocytes, and fibroblasts. Their bulb-shaped membrane …
adipocytes, endothelial cells, myocytes, and fibroblasts. Their bulb-shaped membrane …
The chemical inhibitors of endocytosis: from mechanisms to potential clinical applications
Endocytosis is one of the major ways cells communicate with their environment. This
process is frequently hijacked by pathogens. Endocytosis also participates in the oncogenic …
process is frequently hijacked by pathogens. Endocytosis also participates in the oncogenic …
Ultrafast widefield mid-infrared photothermal heterodyne imaging
Mid-infrared photothermal (MIP) microscopy is a valuable tool for sensitive and fast chemical
imaging with high spatial resolution beyond the mid-infrared diffraction limit. The highest …
imaging with high spatial resolution beyond the mid-infrared diffraction limit. The highest …
The molecular organization of differentially curved caveolae indicates bendable structural units at the plasma membrane
Caveolae are small coated plasma membrane invaginations with diverse functions.
Caveolae undergo curvature changes. Yet, it is unclear which proteins regulate this process …
Caveolae undergo curvature changes. Yet, it is unclear which proteins regulate this process …