CD36 as a gatekeeper of myocardial lipid metabolism and therapeutic target for metabolic disease

JFC Glatz, LC Heather… - Physiological reviews, 2024 - journals.physiology.org
The multifunctional membrane glycoprotein CD36 is expressed in different types of cells and
plays a key regulatory role in cellular lipid metabolism, especially in cardiac muscle. CD36 …

Nanoparticle entry into cells; the cell biology weak link

G Griffiths, J Gruenberg, M Marsh, J Wohlmann… - Advanced Drug Delivery …, 2022 - Elsevier
Nanoparticles (NP) are attractive options for the therapeutic delivery of active
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …

Hypoxia-induced macropinocytosis represents a metabolic route for liver cancer

MS Zhang, JD Cui, D Lee, VWH Yuen… - Nature …, 2022 - nature.com
Hepatocellular carcinoma (HCC) invariably exhibits inadequate O2 (hypoxia) and nutrient
supply. Hypoxia-inducible factor (HIF) mediates cascades of molecular events that enable …

Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system

FN Lolo, N Walani, E Seemann, D Zalvidea… - Nature cell …, 2023 - nature.com
In response to different types and intensities of mechanical force, cells modulate their
physical properties and adapt their plasma membrane (PM). Caveolae are PM nano …

Caveolae: Mechanosensing and mechanotransduction devices linking membrane trafficking to mechanoadaptation

MA Del Pozo, FN Lolo, A Echarri - Current opinion in cell biology, 2021 - Elsevier
Mechanical forces (extracellular matrix stiffness, vascular shear stress, and muscle
stretching) reaching the plasma membrane (PM) determine cell behavior. Caveolae are PM …

Interplay between lipid metabolism, lipid droplets, and DNA virus infections

MA Farías, B Diethelm-Varela, AJ Navarro, AM Kalergis… - Cells, 2022 - mdpi.com
Lipid droplets (LDs) are cellular organelles rich in neutral lipids such as triglycerides and
cholesterol esters that are coated by a phospholipid monolayer and associated proteins …

Energy and dynamics of caveolae trafficking

C Matthaeus, JW Taraska - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Caveolae are 70–100 nm diameter plasma membrane invaginations found in abundance in
adipocytes, endothelial cells, myocytes, and fibroblasts. Their bulb-shaped membrane …

The chemical inhibitors of endocytosis: from mechanisms to potential clinical applications

OK Szewczyk-Roszczenko, P Roszczenko… - Cells, 2023 - mdpi.com
Endocytosis is one of the major ways cells communicate with their environment. This
process is frequently hijacked by pathogens. Endocytosis also participates in the oncogenic …

Ultrafast widefield mid-infrared photothermal heterodyne imaging

EM Paiva, FM Schmidt - Analytical Chemistry, 2022 - ACS Publications
Mid-infrared photothermal (MIP) microscopy is a valuable tool for sensitive and fast chemical
imaging with high spatial resolution beyond the mid-infrared diffraction limit. The highest …

The molecular organization of differentially curved caveolae indicates bendable structural units at the plasma membrane

C Matthaeus, KA Sochacki, AM Dickey… - Nature …, 2022 - nature.com
Caveolae are small coated plasma membrane invaginations with diverse functions.
Caveolae undergo curvature changes. Yet, it is unclear which proteins regulate this process …