Lipid nanoparticles strategies to modify pharmacokinetics of central nervous system targeting drugs: Crossing or circumventing the blood–brain barrier (BBB) to …
The main limitation to the success of central nervous system (CNS) therapies lies in the
difficulty for drugs to cross the blood–brain barrier (BBB) and reach the brain. Regarding its …
difficulty for drugs to cross the blood–brain barrier (BBB) and reach the brain. Regarding its …
Pharmacokinetics and pharmacodynamics of intranasal solid lipid nanoparticles and nanostructured lipid carriers for nose-to-brain delivery
Nose-to-brain drug delivery has been of great interest for the treatment of many central
nervous system (CNS) diseases and psychiatric disorders over past decades. Several …
nervous system (CNS) diseases and psychiatric disorders over past decades. Several …
Graphene quantum dots as a potential diagnostic and therapeutic tool for the management of Alzheimer's disease
Alzheimer's disease (AD) is one of the most common forms of dementia, affecting more than
50 million people globally. The onset of AD is linked to age, smoking, obesity …
50 million people globally. The onset of AD is linked to age, smoking, obesity …
Nose to brain delivery of donepezil through surface modified NLCs: Formulation development, optimization, and brain targeting study
M Yasir, A Zafar, KM Noorulla, AJ Tura… - Journal of Drug Delivery …, 2022 - Elsevier
The research was aimed to formulate the Donepezil (DPZ)-loaded nanostructured lipid
carriers (NLCs) and coated with chitosan (CH) for brain targeting through the intranasal …
carriers (NLCs) and coated with chitosan (CH) for brain targeting through the intranasal …
Recent advances in intranasal administration for brain-targeting delivery: a comprehensive review of lipid-based nanoparticles and stimuli-responsive gel formulations
J Koo, C Lim, KT Oh - International Journal of Nanomedicine, 2024 - Taylor & Francis
Addressing disorders related to the central nervous system (CNS) remains a complex
challenge because of the presence of the blood-brain barrier (BBB), which restricts the entry …
challenge because of the presence of the blood-brain barrier (BBB), which restricts the entry …
Lipid-based nanocarriers for neurological disorders: a review of the state-of-the-art and therapeutic success to date
Neurodegenerative disorders including Alzheimer's, Parkinson's, and dementia are chronic
and advanced diseases that are associated with loss of neurons and other related …
and advanced diseases that are associated with loss of neurons and other related …
Development and optimization of imiquimod-loaded nanostructured lipid carriers using a hybrid design of experiments approach
Background Imiquimod (IMQ) is an immunomodulating drug that is approved for the
treatment of superficial basal cell carcinoma, actinic keratosis, external genital warts and …
treatment of superficial basal cell carcinoma, actinic keratosis, external genital warts and …
Nose to brain delivery of astaxanthin–loaded nanostructured lipid carriers in rat model of Alzheimer's disease: Preparation, in vitro and in vivo evaluation
MK Shehata, AA Ismail, MA Kamel - International Journal of …, 2023 - Taylor & Francis
Background Astaxanthin (AST) is a second-generation antioxidant with anti-inflammatory
and neuroprotective properties and could be a promising candidate for Alzheimer's disease …
and neuroprotective properties and could be a promising candidate for Alzheimer's disease …
Design of experiment (DoE) as a quality by design (QbD) tool to optimise formulations of lipid nanoparticles for nose-to-brain drug delivery
AC Correia, JN Moreira, JM Sousa Lobo… - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction The nose-to-brain route has been widely investigated to improve drug targeting
to the central nervous system (CNS), where lipid nanoparticles (solid lipid nanoparticles …
to the central nervous system (CNS), where lipid nanoparticles (solid lipid nanoparticles …
[HTML][HTML] The prescription design and key properties of nasal gel for CNS drug delivery: A review
M Wang, X Ma, S Zong, Y Su, R Su, H Zhang… - European Journal of …, 2024 - Elsevier
Central nervous system (CNS) diseases are among the major health problems. However,
blood-brain barrier (BBB) makes traditional oral and intravenous delivery of CNS drugs …
blood-brain barrier (BBB) makes traditional oral and intravenous delivery of CNS drugs …