The functional impact of mitochondrial structure across subcellular scales

B Glancy, Y Kim, P Katti, TB Willingham - Frontiers in physiology, 2020 - frontiersin.org
Mitochondria are key determinants of cellular health. However, the functional role of
mitochondria varies from cell to cell depending on the relative demands for energy …

Mitochondrial dysfunction in diabetic kidney disease

JM Forbes, DR Thorburn - Nature Reviews Nephrology, 2018 - nature.com
Globally, diabetes is the leading cause of chronic kidney disease and end-stage renal
disease, which are major risk factors for cardiovascular disease and death. Despite this …

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

K McArthur, LW Whitehead, JM Heddleston, L Li… - Science, 2018 - science.org
INTRODUCTION There has been an explosion of interest in the role of cell death pathways
and damage-associated molecular pattern (DAMP) signaling in sha** inflammatory and …

Mitochondrial dynamics controls T cell fate through metabolic programming

MD Buck, D O'Sullivan, RIK Geltink, JD Curtis… - Cell, 2016 - cell.com
Summary Activated effector T (TE) cells augment anabolic pathways of metabolism, such as
aerobic glycolysis, while memory T (TM) cells engage catabolic pathways, like fatty acid …

Multiple cell death modalities and their key features

GE Yan, M Elbadawi, T Efferth - World Academy of …, 2020 - spandidos-publications.com
Cell death, as a final cellular decision which is reached following complex communications,
represents a critical process with which to maintain organismic homeostasis. Different …

The nature of the mechanical bond: from molecules to machines

CJ Bruns, JF Stoddart - 2016 - books.google.com
" The story is told by THE inventor-pioneer-master in the field and is accompanied by
amazing illustrations...[it] will become an absolute reference and a best seller in chemistry!" …

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

EQ Toyama, S Herzig, J Courchet, TL Lewis Jr… - Science, 2016 - science.org
Mitochondria undergo fragmentation in response to electron transport chain (ETC) poisons
and mitochondrial DNA–linked disease mutations, yet how these stimuli mechanistically …

Mechanisms of muscle insulin resistance and the cross‐talk with liver and adipose tissue

SC da Silva Rosa, N Nayak, AM Caymo… - Physiological …, 2020 - Wiley Online Library
Insulin resistance is a metabolic disorder affecting multiple tissues and is a precursor event
to type 2 diabetes (T2D). As T2D affects over 425 million people globally, there is an …

Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth

JA Kashatus, A Nascimento, LJ Myers, A Sher… - Molecular cell, 2015 - cell.com
Ras is mutated in up to 30% of cancers, including 90% of pancreatic ductal
adenocarcinomas, causing it to be constitutively GTP-bound, and leading to activation of …

[HTML][HTML] Fullerene: biomedical engineers get to revisit an old friend

S Goodarzi, T Da Ros, J Conde, F Sefat, M Mozafari - Materials Today, 2017 - Elsevier
In 1985, the serendipitous discovery of fullerene triggered the research of carbon structures
into the world of symmetric nanomaterials. Consequently, Robert F. Curl, Harold W. Kroto …