The heterogeneity of tissue macrophages, in health and in disease, has become
increasingly transparent over the last decade. But with the plethora of data comes a natural …

Macrophages are essential for the maintenance of intestinal homeostasis, yet appear to be
drivers of inflammation in the context of inflammatory bowel disease (IBD). How these …

Human monocytes are divided in three major populations; classical (CD14+ CD16−), non-
classical (CD14dimCD16+), and intermediate (CD14+ CD16+). Each of these subsets is …

Novel experimental approaches such as fate-map** and single-cell analysis have brought
fresh insight into monocyte development and function over the past decade and helped …

Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitors that have
numerous shared characteristics between mice and humans. Human counterparts of mouse …

IFNγ is a cytokine with important roles in tissue homeostasis, immune and inflammatory
responses and tumour immunosurveillance. Signalling by the IFNγ receptor activates the …

Dendritic cells are powerful antigen-presenting cells that are essential for the priming of T
cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules …

BACKGROUND Host immune responses are classically divided into innate immune
responses, which react rapidly and nonspecifically upon encountering a pathogen, and …

The gastrointestinal tract has the important task of absorbing nutrients, a complex process
that requires an intact barrier allowing the passage of nutrients but that simultaneously …

Macrophages are increasingly recognized as essential players in the maintenance of
intestinal homeostasis and as key sentinels of the intestinal immune system. However …