Antibodies are proteins that recognize the molecular surfaces of potentially noxious
molecules to mount an adaptive immune response or, in the case of autoimmune diseases …

Broadly neutralizing antibodies (bnAbs) can protect against HIV infection but have not been
induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare …

A popular approach to protein design is to combine a generative model with a discriminative
model for conditional sampling. The generative model samples plausible sequences while …

Attention-based models trained on protein sequences have demonstrated incredible
success at classification and generation tasks relevant for artificial-intelligence-driven …

Discovery and optimization of monoclonal antibodies for therapeutic applications relies on
large sequence libraries but is hindered by developability issues such as low solubility, high …

The antibody repertoires of individuals and groups have been used to explore disease
states, understand vaccine responses, and drive therapeutic development. The arrival of B …

Single domain antibodies (sdAbs) are gaining a reputation as superior recognition elements
as they combine the advantages of the specificity and affinity found in conventional …

Cost-effective, efficacious therapeutics are urgently needed to combat the COVID-19
pandemic. In this study, we used camelid immunization and proteomics to identify a large …

Motivation The emergence of a novel strain of betacoronavirus, SARS-CoV-2, has led to a
pandemic that has been associated with over 700 000 deaths as of August 5, 2020 …

Immune receptor proteins play a key role in the immune system and have shown great
promise as biotherapeutics. The structure of these proteins is critical for understanding their …