Pre-twisting for improved genome modification and miRNA targeting
Two reports by Dhuri et al. and Oyaghire et al., respectively, show that, through installing
chiral centers at the backbone of the artificial nucleic acid, peptide nucleic acid (PNA) …
chiral centers at the backbone of the artificial nucleic acid, peptide nucleic acid (PNA) …
Peptide nucleic acids: Recent advancements and future opportunities in biomedical applications
Peptide nucleic acids (PNA), synthetic molecules comprising a peptide-like backbone and
natural and unnatural nucleobases, have garnered significant attention for their potential …
natural and unnatural nucleobases, have garnered significant attention for their potential …
Anti-gene oligonucleotide clamps invade dsDNA and downregulate huntingtin expression
T Umek, KE Lundin, MO Mowoe, Y Hao, S Roudi… - … Therapy Nucleic Acids, 2024 - cell.com
Anti-gene oligonucleotides belong to a group of therapeutic compounds, which, in contrast
to antisense oligonucleotides, bind to DNA. Clamp anti-gene oligonucleotides bind through …
to antisense oligonucleotides, bind to DNA. Clamp anti-gene oligonucleotides bind through …
Harnessing Peptide Nucleic Acids and the Eukaryotic Resolvase MOC1 for Programmable, Precise Generation of Double-Strand DNA Breaks
Programmable site-specific nucleases (SSNs) hold extraordinary promise to unlock myriad
gene editing applications in medicine and agriculture. However, develo** small and …
gene editing applications in medicine and agriculture. However, develo** small and …
Impact of charges on the hybridization kinetics and thermal stability of PNA duplexes
M López-Tena, N Winssinger - Organic & Biomolecular Chemistry, 2024 - pubs.rsc.org
Peptide nucleic acid (PNA) is prominent artificial nucleic acid mimetic and modifications at
the-position of the peptidic backbone are known to further enhance the desirable …
the-position of the peptidic backbone are known to further enhance the desirable …
Systemic in utero gene editing as a treatment for cystic fibrosis
In utero gene editing has the potential to modify disease causing genes in multiple
develo** tissues before birth, possibly allowing for normal organ development, disease …
develo** tissues before birth, possibly allowing for normal organ development, disease …