Classification and basic pathology of Alzheimer disease
C Duyckaerts, B Delatour, MC Potier - Acta neuropathologica, 2009 - Springer
The lesions of Alzheimer disease include accumulation of proteins, losses of neurons and
synapses, and alterations related to reactive processes. Extracellular Aβ accumulation …
synapses, and alterations related to reactive processes. Extracellular Aβ accumulation …
[HTML][HTML] Biochemical detection of Aβ isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease
Prior to the identification of the various abnormal proteins deposited as fibrillar aggregates in
the Alzheimer's disease (AD) brain, there was tremendous controversy over the importance …
the Alzheimer's disease (AD) brain, there was tremendous controversy over the importance …
RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory
Memory function often declines with age, and is believed to deteriorate initially because of
changes in synaptic function rather than loss of neurons. Some individuals then go on to …
changes in synaptic function rather than loss of neurons. Some individuals then go on to …
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
Point mutations in the presenilin-1 gene (PS1) are a major cause of familial Alzheimer's
disease. They result in a selective increase in the production of the amyloidogenic peptide …
disease. They result in a selective increase in the production of the amyloidogenic peptide …
[HTML][HTML] Intraneuronal Aβ42 accumulation in human brain
Alzheimer's disease (AD) is characterized by the deposition of senile plaques (SPs) and
neurofibrillary tangles (NFTs) in vulnerable brain regions. SPs are composed of aggregated …
neurofibrillary tangles (NFTs) in vulnerable brain regions. SPs are composed of aggregated …
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins
Missense mutations in two related genes, termed presenilin 1 (PS1) and presenilin 2 (PS2),
cause dementia in a subset of early-onset familial Alzheimer's disease (FAD) pedigrees. In a …
cause dementia in a subset of early-onset familial Alzheimer's disease (FAD) pedigrees. In a …
Resveratrol promotes clearance of Alzheimer's disease amyloid-β peptides
Several epidemiological studies indicate that moderate consumption of wine is associated
with a lower incidence of Alzheimer's disease. Wine is enriched in antioxidant compounds …
with a lower incidence of Alzheimer's disease. Wine is enriched in antioxidant compounds …
A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model
Alzheimer disease (AD) is characterized by excessive deposition of amyloid β-peptides (Aβ
peptides) in the brain. In the nonamyloidogenic pathway, the amyloid precursor protein …
peptides) in the brain. In the nonamyloidogenic pathway, the amyloid precursor protein …
Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1
YM Li, M Xu, MT Lai, Q Huang, JL Castro… - Nature, 2000 - nature.com
Cleavage of amyloid precursor protein (APP) by the β-and γ-secretases generates the
amino and carboxy termini, respectively, of the Aβ amyloidogenic peptides Aβ40 and Aβ42 …
amino and carboxy termini, respectively, of the Aβ amyloidogenic peptides Aβ40 and Aβ42 …
Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain
D Moechars, I Dewachter, K Lorent, D Reversé… - Journal of Biological …, 1999 - ASBMB
Transgenic mice overexpressing different forms of amyloid precursor protein (APP), ie wild
type or clinical mutants, displayed an essentially comparable early phenotype in terms of …
type or clinical mutants, displayed an essentially comparable early phenotype in terms of …