Activation or exhaustion of CD8+ T cells in patients with COVID-19
In addition to CD4+ T cells and neutralizing antibodies, CD8+ T cells contribute to protective
immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID …
immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID …
Regulation and function of the PD-L1 checkpoint
Expression of programmed death-ligand 1 (PD-L1) is frequently observed in human
cancers. Binding of PD-L1 to its receptor PD-1 on activated T cells inhibits anti-tumor …
cancers. Binding of PD-L1 to its receptor PD-1 on activated T cells inhibits anti-tumor …
The many faces of the anti-COVID immune response
SA Vardhana, JD Wolchok - Journal of Experimental Medicine, 2020 - rupress.org
Disclosures: SA Vardhana reported personal fees from Immunai and personal fees from
ADC Therapeutics outside the submitted work; in addition, SA Vardhana had a patent to …
ADC Therapeutics outside the submitted work; in addition, SA Vardhana had a patent to …
Anti-PD-1 and anti-CTLA-4 therapies in cancer: mechanisms of action, efficacy, and limitations
JA Seidel, A Otsuka, K Kabashima - Frontiers in oncology, 2018 - frontiersin.org
Melanoma, a skin cancer associated with high mortality rates, is highly radio-and
chemotherapy resistant but can also be very immunogenic. These circumstances have led to …
chemotherapy resistant but can also be very immunogenic. These circumstances have led to …
The diverse functions of the PD1 inhibitory pathway
AH Sharpe, KE Pauken - Nature Reviews Immunology, 2018 - nature.com
T cell activation is a highly regulated process involving peptide–MHC engagement of the T
cell receptor and positive costimulatory signals. Upon activation, coinhibitory'checkpoints' …
cell receptor and positive costimulatory signals. Upon activation, coinhibitory'checkpoints' …
The role of PD-1 in acute and chronic infection
JM Jubel, ZR Barbati, C Burger, DC Wirtz… - Frontiers in …, 2020 - frontiersin.org
PD-1 as an immune checkpoint molecule down-regulates T cell activity during immune
responses in order to prevent autoimmune tissue damage. In chronic infections or tumors …
responses in order to prevent autoimmune tissue damage. In chronic infections or tumors …
T-helper cell subset response is a determining factor in COVID-19 progression
FJ Gil-Etayo, P Suàrez-Fernández… - Frontiers in cellular …, 2021 - frontiersin.org
The immune response type organized against viral infection is determinant in the prognosis
of some infections. This work has aimed to study Th polarization in acute COVID-19 and its …
of some infections. This work has aimed to study Th polarization in acute COVID-19 and its …
The CD8 T cell response to respiratory virus infections
ME Schmidt, SM Varga - Frontiers in immunology, 2018 - frontiersin.org
Humans are highly susceptible to infection with respiratory viruses including respiratory
syncytial virus (RSV), influenza virus, human metapneumovirus, rhinovirus, coronavirus, and …
syncytial virus (RSV), influenza virus, human metapneumovirus, rhinovirus, coronavirus, and …
The PD-1/PD-L1 axis and virus infections: a delicate balance
G Schönrich, MJ Raftery - Frontiers in cellular and infection …, 2019 - frontiersin.org
Programmed cell death protein (PD-1) and its ligands play a fundamental role in the evasion
of tumor cells from antitumor immunity. Less well appreciated is the fact that the PD-1/PD-L1 …
of tumor cells from antitumor immunity. Less well appreciated is the fact that the PD-1/PD-L1 …
[HTML][HTML] Emerging concepts in PD-1 checkpoint biology
KE Pauken, JA Torchia, A Chaudhri, AH Sharpe… - Seminars in …, 2021 - Elsevier
The PD-1 pathway is a cornerstone in immune regulation. While the PD-1 pathway has
received considerable attention for its role in contributing to the maintenance of T cell …
received considerable attention for its role in contributing to the maintenance of T cell …