Alzheimer's disease (AD) is the foremost type of dementia that afflicts considerable morbidity
and mortality in aged population. Several transcription molecules, pathways, and molecular …

Ever since the discovery of thyroid hormone deficiency as the primary cause of cretinism in
the second half of the 19th century, the crucial role of thyroid hormone (TH) signaling in …

Since the discovery of L-thyroxine, the main secretory product of the thyroid gland, and its
major metabolite T3, which exerts the majority of thyroid hormone action via ligand …

Neurodegenerative diseases (NDDs) are progressive multifactorial disorders of the nervous
system sharing common pathogenic features, including intracellular misfolded protein …

Hydrogen sulphide has recently drawn much attention due to its potent anti-inflammatory
and neuroprotective roles in brain functions. The purpose of the current study was to exploit …

There is a need for innovation with respect to therapeutics in psychiatry. Available evidence
indicates that the trace amine-associated receptor 1 (TAAR1) agonist SEP-363856 is …

CLN8 is an endoplasmic reticulum cargo receptor and a regulator of lysosome biogenesis
whose loss of function leads to neuronal ceroid lipofuscinosis. CLN8 has been linked to …

Multiple lines of evidence suggest that the trace amine-associated receptor 1 (TAAR1) holds
promise as a potential target for stress-related disorders, such as treating major depressive …

The thyroid is an essential endocrine organ in human body, and thyroid hormones (THs) are
pivotal signaling molecules and mediators in various physiological processes. THs …

Many xenobiotics are identified as potential thyroid disruptors due to their action to reduce
circulating levels of thyroid hormone, most notably thyroxine (T4). Developmental …