The lamin protein family

TA Dittmer, T Misteli - Genome biology, 2011 - Springer
The lamins are the major architectural proteins of the animal cell nucleus. Lamins line the
inside of the nuclear membrane, where they provide a platform for the binding of proteins …

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

T Dechat, K Pfleghaar, K Sengupta, T Shimi… - Genes & …, 2008 - genesdev.cshlp.org
Over the past few years it has become evident that the intermediate filament proteins, the
types A and B nuclear lamins, not only provide a structural framework for the nucleus, but …

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

KJ Roux, DI Kim, M Raida, B Burke - Journal of cell biology, 2012 - rupress.org
Abbreviations used in this paper: BAT, biotin acceptor tag; bioAMP, biotinoyl-5-AMP; BioID,
proximity-dependent biotin identification; BirA*, BirA-R118G; INM, inner nuclear membrane; …

Constitutive nuclear lamina–genome interactions are highly conserved and associated with A/T-rich sequence

W Meuleman, D Peric-Hupkes, J Kind… - Genome …, 2013 - genome.cshlp.org
In metazoans, the nuclear lamina is thought to play an important role in the spatial
organization of interphase chromosomes, by providing anchoring sites for large genomic …

Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction

UC Sharma, S Pokharel, TJ Van Brakel, JH Van Berlo… - Circulation, 2004 - ahajournals.org
Background—Inflammatory mechanisms have been proposed to be important in heart
failure (HF), and cytokines have been implicated to add to the progression of HF. However, it …

Nuclear lamins

T Dechat, SA Adam, P Taimen… - Cold Spring …, 2010 - cshperspectives.cshlp.org
The nuclear lamins are type V intermediate filament proteins that are critically important for
the structural properties of the nucleus. In addition, they are involved in the regulation of …

Real-time single-molecule imaging of the infection pathway of an adeno-associated virus

G Seisenberger, MU Ried, T Endress, H Buning… - Science, 2001 - science.org
We describe a method, based on single-molecule imaging, that allows the real-time
visualization of the infection pathway of single viruses in living cells, each labeled with only …

The A-and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription

T Shimi, K Pfleghaar, S Kojima, CG Pack… - Genes & …, 2008 - genesdev.cshlp.org
The nuclear lamins function in the regulation of replication, transcription, and epigenetic
modifications of chromatin. However, the mechanisms responsible for these lamin functions …

Nuclear lamins: building blocks of nuclear architecture

RD Goldman, Y Gruenbaum, RD Moir… - Genes & …, 2002 - genesdev.cshlp.org
Nuclear lamins were initially identified as the major components of the nuclear lamina, a
proteinaceous layer found at the interface between chromatin and the inner nuclear …

Nuclear lamins: laminopathies and their role in premature ageing

JLV Broers, FCS Ramaekers, G Bonne… - Physiological …, 2006 - journals.physiology.org
It has been demonstrated that nuclear lamins are important proteins in maintaining cellular
as well as nuclear integrity, and in maintaining chromatin organization in the nucleus …