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RNA modifications: importance in immune cell biology and related diseases
RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …
including generation, transportation, function, and metabolization, they act as critical …
Chemically modified platforms for better RNA therapeutics
RNA-based therapies have catalyzed a revolutionary transformation in the biomedical
landscape, offering unprecedented potential in disease prevention and treatment. However …
landscape, offering unprecedented potential in disease prevention and treatment. However …
The potential role of N7-methylguanosine (m7G) in cancer
Y Luo, Y Yao, P Wu, X Zi, N Sun, J He - Journal of hematology & oncology, 2022 - Springer
Abstract N 7-methylguanosine (m7G), one of the most prevalent RNA modifications, has
recently attracted significant attention. The m7G modification actively participates in …
recently attracted significant attention. The m7G modification actively participates in …
QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism
Summary N 7-methylguanosine (m 7 G) modification, routinely occurring at mRNA 5′ cap
or within tRNAs/rRNAs, also exists internally in messenger RNAs (mRNAs). Although m 7 G …
or within tRNAs/rRNAs, also exists internally in messenger RNAs (mRNAs). Although m 7 G …
RNA modifications in cancer
Currently, more than 170 modifications have been identified on RNA. Among these RNA
modifications, various methylations account for two-thirds of total cases and exist on almost …
modifications, various methylations account for two-thirds of total cases and exist on almost …
N7-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis
Mis-regulated RNA modifications promote the processing and translation of oncogenic
mRNAs to facilitate cancer progression, while the molecular mechanisms remain unclear …
mRNAs to facilitate cancer progression, while the molecular mechanisms remain unclear …
METTL1-Mediated m7G tRNA Modification Promotes Lenvatinib Resistance in Hepatocellular Carcinoma
M Huang, J Long, Z Yao, Y Zhao, Y Zhao, J Liao… - Cancer …, 2023 - aacrjournals.org
The tyrosine kinase inhibitor lenvatinib is a first-line drug for treating patients with advanced
hepatocellular carcinoma (HCC). However, its efficacy is severely hampered by drug …
hepatocellular carcinoma (HCC). However, its efficacy is severely hampered by drug …
RNA modification: mechanisms and therapeutic targets
RNA modifications are dynamic and reversible chemical modifications on substrate RNA
that are regulated by specific modifying enzymes. They play important roles in the regulation …
that are regulated by specific modifying enzymes. They play important roles in the regulation …
tRNA dysregulation and disease
Abstract tRNAs are key adaptor molecules that decipher the genetic code during translation
of mRNAs in protein synthesis. In contrast to the traditional view of tRNAs as ubiquitously …
of mRNAs in protein synthesis. In contrast to the traditional view of tRNAs as ubiquitously …
Methyltransferase-like proteins in cancer biology and potential therapeutic targeting
RNA modification has recently become a significant process of gene regulation, and the
methyltransferase-like (METTL) family of proteins plays a critical role in RNA modification …
methyltransferase-like (METTL) family of proteins plays a critical role in RNA modification …