Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing)
bacteria that survive in stress environments such as antibiotic exposure, acidic and …

Endogenous indole and its derivatives (indoles), considered as promising N-substituted
heterocyclic compounds, are tryptophan metabolites derived from intestinal microbiota and …

Microorganisms produce and excrete a versatile array of metabolites with different physico-
chemical properties and biological activities. However, the ability of microorganisms to …

Although metabolism plays an active role in antibiotic lethality, antibiotic resistance is
generally associated with drug target modification, enzymatic inactivation, and/or transport …

Controlled experimental evolution during antibiotic treatment can help to explain the
processes leading to antibiotic resistance in bacteria. Recently, intermittent antibiotic …

The agricultural ecosystem creates a platform for the development and dissemination of
antimicrobial resistance, which is promoted by the indiscriminate use of antibiotics in the …

A key aspect of bacterial survival is the ability to evolve while migrating across spatially
varying environmental challenges. Laboratory experiments, however, often study evolution …

BACKGROUND Antibiotics are among the most important tools in medicine, but their efficacy
is threatened by the evolution of resistance. Since the earliest days of antibiotics, resistance …

Surface-associated microbial communities, called biofilms, are present in all environments.
Although biofilms play an important positive role in a variety of ecosystems, they also have …

The widespread use of antibiotics results in the generation of antibiotic concentration
gradients in humans, livestock and the environment. Thus, bacteria are frequently exposed …