P2X receptors are membrane ion channels that open in response to the binding of
extracellular ATP. Seven genes in vertebrates encode P2X receptor subunits, which are 40 …

Mammalian ATP-gated nonselective cation channels (P2XRs) can be composed of seven
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …

Nearly sixty years ago Fredrich Timm developed a histochemical technique that revealed a
rich reserve of free zinc in distinct regions of the brain. Subsequent electron microscopy …

The charge of this invited review is to present a convincing case for the fact that cells release
their ATP for physiological reasons. Many of our “purinergic” colleagues as well as …

Acidosis is a noxious condition associated with inflammation, ischaemia or defective acid
containment. As a consequence, acid sensing has evolved as an important property of …

Significant progress in understanding the pharmacological characteristics and physiological
importance of homomeric and heteromeric P2X channels has been achieved in recent …

1. INTRODUCTION Ligand-gated ion channels (LGICs) mediate intercellular communication
by converting the binding of a neurotransmitter that is released from the presynaptic terminal …

Abstract ATP-gated P2X receptors are trimeric ion channels selective to cations. Recent
progress in the molecular biophysics of these channels enables a better understanding of …

Transcripts and/or proteins of P2X receptor (P2XR) subunits have been found in virtually all
mammalian tissues. Generally more than one of the seven known P2X subunits have been …

Neurons of the central nervous system (CNS) are endowed with ATP-sensitive receptors
belonging to the P2X (ligand-gated cationic channels) and P2Y (G protein-coupled …