Insights for precision oncology from the integration of genomic and clinical data of 13,880 tumors from the 100,000 Genomes Cancer Programme
Abstract The Cancer Programme of the 100,000 Genomes Project was an initiative to
provide whole-genome sequencing (WGS) for patients with cancer, evaluating opportunities …
provide whole-genome sequencing (WGS) for patients with cancer, evaluating opportunities …
[HTML][HTML] Mutational Signatures in Colorectal Cancer: Translational Insights, Clinical Applications, and Limitations
G Crisafulli - Cancers, 2024 - mdpi.com
Simple Summary This review provides a comprehensive overview of the current knowledge
on mutational signatures in colorectal cancer (CRC), highlighting their potential clinical …
on mutational signatures in colorectal cancer (CRC), highlighting their potential clinical …
Prognostic genome and transcriptome signatures in colorectal cancers
Colorectal cancer is caused by a sequence of somatic genomic alterations affecting driver
genes in core cancer pathways. Here, to understand the functional and prognostic impact of …
genes in core cancer pathways. Here, to understand the functional and prognostic impact of …
[HTML][HTML] Genetic immune escape in cancer: timing and implications for treatment
Genetic immune escape (GIE) alterations pose a significant challenge in cancer by enabling
tumors to evade immune detection. These alterations, which can vary significantly across …
tumors to evade immune detection. These alterations, which can vary significantly across …
Colorectal cancer patients-derived immunity-organoid platform unveils cancer-specific tissue markers associated with immunotherapy resistance
Colorectal cancer (CRC) is a devastating disease, ranking as the second leading cause of
cancer-related deaths worldwide. Immune checkpoint inhibitors (ICIs) have emerged as …
cancer-related deaths worldwide. Immune checkpoint inhibitors (ICIs) have emerged as …
Comprehensive repertoire of the chromosomal alteration and mutational signatures across 16 cancer types from 10,983 cancer patients
Whole genome sequencing (WGS) allows exploration of the complete compendium of
oncogenic processes generating characteristic patterns of mutations. Mutational signatures …
oncogenic processes generating characteristic patterns of mutations. Mutational signatures …
Search for germline gene variants in colorectal cancer families presenting with multiple primary colorectal cancers
A Försti, F Ambrozkiewicz, M Marciniak… - … Journal of Cancer, 2025 - Wiley Online Library
A double primary colorectal cancer (CRC) in a familial setting signals a high risk of CRC. In
order to identify novel CRC susceptibility genes, we whole‐exome sequenced germline …
order to identify novel CRC susceptibility genes, we whole‐exome sequenced germline …
The ATOM-Seq sequence capture panel can accurately predict microsatellite instability status in formalin-fixed tumour samples, alongside routine gene mutation …
Microsatellite instability (MSI) occurs across a number of cancers and is associated with
different clinical characteristics when compared to microsatellite stable (MSS) cancers. As …
different clinical characteristics when compared to microsatellite stable (MSS) cancers. As …
A comprehensive comparison of tools for fitting mutational signatures
Mutational signatures connect characteristic mutational patterns in the genome with
biological or chemical processes that take place in cancers. Analysis of mutational …
biological or chemical processes that take place in cancers. Analysis of mutational …
[HTML][HTML] Estimating the Number of Polygenic Diseases Among Six Mutually Exclusive Entities of Non-Tumors and Cancer
CIE Smith, JA Burger, R Zain - International journal of molecular sciences, 2024 - mdpi.com
In the era of precision medicine with increasing amounts of sequenced cancer and non-
cancer genomes of different ancestries, we here enumerate the resulting polygenic disease …
cancer genomes of different ancestries, we here enumerate the resulting polygenic disease …