Understanding and overcoming resistance to PARP inhibitors in cancer therapy
Develo** novel targeted anticancer therapies is a major goal of current research. The use
of poly (ADP-ribose) polymerase (PARP) inhibitors in patients with homologous …
of poly (ADP-ribose) polymerase (PARP) inhibitors in patients with homologous …
Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers
P Schwertman, S Bekker-Jensen… - Nature reviews Molecular …, 2016 - nature.com
DNA double-strand breaks (DSBs) are highly cytotoxic DNA lesions. The swift recognition
and faithful repair of such damage is crucial for the maintenance of genomic stability, as well …
and faithful repair of such damage is crucial for the maintenance of genomic stability, as well …
[HTML][HTML] Proteome-wide identification of poly (ADP-Ribosyl) ation targets in different genotoxic stress responses
S Jungmichel, F Rosenthal, M Altmeyer, J Lukas… - Molecular cell, 2013 - cell.com
Summary Poly (ADP-ribos) ylation (PARylation) is a reversible posttranslational modification
found in higher eukaryotes. However, little is known about PARylation acceptor proteins …
found in higher eukaryotes. However, little is known about PARylation acceptor proteins …
The role of poly ADP-ribosylation in the first wave of DNA damage response
Poly ADP-ribose polymerases (PARPs) catalyze massive protein poly ADP-ribosylation
(PARylation) within seconds after the induction of DNA single-or double-strand breaks …
(PARylation) within seconds after the induction of DNA single-or double-strand breaks …
The enigmatic function of PARP1: from PARylation activity to PAR readers
T Kamaletdinova, Z Fanaei-Kahrani, ZQ Wang - Cells, 2019 - mdpi.com
Poly (ADP-ribosyl) ation (PARylation) is catalysed by poly (ADP-ribose) polymerases
(PARPs, also known as ARTDs) and then rapidly removed by degrading enzymes. Poly …
(PARPs, also known as ARTDs) and then rapidly removed by degrading enzymes. Poly …
Spatiotemporal regulation of posttranslational modifications in the DNA damage response
NP Dantuma, H van Attikum - The EMBO journal, 2016 - embopress.org
A timely and accurate cellular response to DNA damage requires tight regulation of the
action of DNA damage response (DDR) proteins at lesions. A multitude of posttranslational …
action of DNA damage response (DDR) proteins at lesions. A multitude of posttranslational …
The ubiquitin ligase TRIP12 limits PARP1 trap** and constrains PARP inhibitor efficiency
PARP inhibitors (PARPi) cause synthetic lethality in BRCA-deficient tumors. Whether
specific vulnerabilities to PARPi exist beyond BRCA mutations and related defects in …
specific vulnerabilities to PARPi exist beyond BRCA mutations and related defects in …
Base excision repair, a pathway regulated by posttranslational modifications
RJ Carter, JL Parsons - Molecular and cellular biology, 2016 - Taylor & Francis
Base excision repair (BER) is an essential DNA repair pathway involved in the maintenance
of genome stability and thus in the prevention of human diseases, such as premature aging …
of genome stability and thus in the prevention of human diseases, such as premature aging …
EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer
Inhibitors against poly (ADP-ribose) polymerase (PARP) are promising targeted agents
currently used to treat BRCA-mutant ovarian cancer and are in clinical trials for other cancer …
currently used to treat BRCA-mutant ovarian cancer and are in clinical trials for other cancer …
The regulation loop of MARVELD1 interacting with PARP1 in DNA damage response maintains genome stability and promotes therapy resistance of cancer cells
H Sun, C Liu, F Han, X Lin, L Cao, C Liu, Q Ji… - Cell Death & …, 2023 - nature.com
The DNA damage response (DDR) plays crucial roles in cancer prevention and therapy.
Poly (ADP-ribose) polymerase 1 (PARP1) mediates multiple signal transduction in the DDR …
Poly (ADP-ribose) polymerase 1 (PARP1) mediates multiple signal transduction in the DDR …