Develo** greener synthesis processes is an inescapable necessity to transform the
industrial landscape, mainly in the pharmaceutical sector, into a long-term, sustainable …

In recent years, there has been a growing interest in therapeutic peptides within the
pharmaceutical industry with more than 50 peptide drugs on the market, approximately 170 …

This review describes the practical aspects involved in the implementation of large-scale
amidations in process chemistry. Coupling reagent, base, additive, and solvent selections …

An analysis of chemical reactions used in current medicinal chemistry (2014), three decades
ago (1984), and in natural product total synthesis has been conducted. The analysis …

Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals |
Organic Process Research & Development ACS ACS Publications C&EN CAS Find my …

In recent years, peptide-coupling reactions have significantly advanced in parallel with the
development of new peptidecoupling reagents, which have been covered in a number of …

A historical overview of peptide chemistry from T. Curtius to E. Fischer to M. Bergmann and
L. Zervas is first presented. Next, the fundamentals of peptide synthesis with a focus on solid …

The great versatility and the inherent high affinities of peptides for their respective targets
have led to tremendous progress for therapeutic applications in the last years. In order to …

The highly refined organic chemistry in solid-phase synthesis has made it the method of
choice not only to assemble peptides but also small proteins–mainly on a laboratory scale …

This work is not a typical review that is trying to cover all coupling reagents in-depth. This is
a personal account—it is written in the first person—seeking to summarize the 25 years of …