Aquaculture supplies the world food market with a significant amount of valuable protein.
Highly productive aquaculture fishes can be derived by utilizing genome-editing methods …

In the dynamic landscape of biomedical science, the pursuit of effective treatments for motor
neuron disorders like hereditary spastic paraplegia (HSP), amyotrophic lateral sclerosis …

The vast neuronal diversity in the human neocortex is vital for high-order brain functions,
necessitating elucidation of the regulatory mechanisms underlying such unparalleled …

The development of cell culture models that recapitulate the etiology and features of nervous
system diseases is central to the discovery of new drugs and their translation onto therapies …

Introduction Recently, chloride channel CLIC‐like 1 (CLCC1) was reported to be a novel
ALS‐related gene. We aimed to screen CLCC1 variants in our ALS cohort and further …

Amyotrophic lateral sclerosis (ALS), first described by Charcot in the 19 th century [1], is a
relentlessly progressive, presently incurable neurodegenerative disorder that causes …

Amyotrophic lateral sclerosis (ALS) is a deadly neurological disease with a complicated and
variable pathophysiology yet to be fully understood. There is currently no effective treatment …

Introduction TP73 was recently identified as a novel causative gene for amyotrophic lateral
sclerosis (ALS). We aimed to determine the contribution of variations in TP73 in the Chinese …

Adenosine deaminase (ADA) is a purine metabolism enzyme that catalyses the breakdown
of adenosine and deoxyadenosine. The enzyme is important in several cellular processes …

Background and purpose TP73 was recently reported to cause amyotrophic lateral sclerosis
(ALS). ALS and frontotemporal dementia (FTD) are considered to form part of a continuum …