[HTML][HTML] Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans
K Pafili, M Roden - Molecular Metabolism, 2021 - Elsevier
Background Nonalcoholic fatty liver disease (NAFLD) comprises hepatic alterations with
increased lipid accumulation (steatosis) without or with inflammation (nonalcoholic …
increased lipid accumulation (steatosis) without or with inflammation (nonalcoholic …
Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease
The global epidemic of obesity has been accompanied by a rising burden of non-alcoholic
fatty liver disease (NAFLD), with manifestations ranging from simple steatosis to non …
fatty liver disease (NAFLD), with manifestations ranging from simple steatosis to non …
Non-alcoholic steatohepatitis: a review of its mechanism, models and medical treatments
Non-alcoholic steatohepatitis (NASH) develops from non-alcoholic fatty liver disease
(NAFLD). Currently, around 25% of the population is estimated to have NAFLD, and 25% of …
(NAFLD). Currently, around 25% of the population is estimated to have NAFLD, and 25% of …
[HTML][HTML] Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD
DG Mashek - Molecular metabolism, 2021 - Elsevier
Background Non-alcoholic fatty liver disease (NAFLD) is defined by the abundance of lipid
droplets (LDs) in hepatocytes. While historically considered simply a depot for energy …
droplets (LDs) in hepatocytes. While historically considered simply a depot for energy …
Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease
The exposure of hepatocytes to high concentrations of lipids and carbohydrates and the
ensuing hepatocellular injury are termed lipotoxicity and glucotoxicity, respectively. A …
ensuing hepatocellular injury are termed lipotoxicity and glucotoxicity, respectively. A …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD
The pathogenic mechanisms underlying the progression of non-alcoholic fatty liver disease
(NAFLD) are not fully understood. In this study, we aimed to assess the relationship between …
(NAFLD) are not fully understood. In this study, we aimed to assess the relationship between …
Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression
Spermidine is a natural polyamine that has health benefits and extends life span in several
species. Deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH) are key …
species. Deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH) are key …
Mouse models of diet-induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease
Background and aims Non-alcoholic steatohepatitis (NASH), the potentially progressive
form of nonalcoholic fatty liver disease (NAFLD), is the pandemic liver disease of our time …
form of nonalcoholic fatty liver disease (NAFLD), is the pandemic liver disease of our time …
[HTML][HTML] Inflammation and fibrosis in chronic liver diseases including non-alcoholic fatty liver disease and hepatitis C
S Tanwar, F Rhodes, A Srivastava… - World journal of …, 2020 - ncbi.nlm.nih.gov
At present chronic liver disease (CLD), the third commonest cause of premature death in the
United Kingdom is detected late, when interventions are ineffective, resulting in …
United Kingdom is detected late, when interventions are ineffective, resulting in …