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Moving beyond the glial scar for spinal cord repair
Traumatic spinal cord injury results in severe and irreversible loss of function. The injury
triggers a complex cascade of inflammatory and pathological processes, culminating in …
triggers a complex cascade of inflammatory and pathological processes, culminating in …
Atomic force microscopy-based mechanobiology
Mechanobiology emerges at the crossroads of medicine, biology, biophysics and
engineering and describes how the responses of proteins, cells, tissues and organs to …
engineering and describes how the responses of proteins, cells, tissues and organs to …
[HTML][HTML] Mechanics in the nervous system: from development to disease
Physical forces are ubiquitous in biological processes across scales and diverse contexts.
This review highlights the significance of mechanical forces in nervous system development …
This review highlights the significance of mechanical forces in nervous system development …
Bioprinting: From Tissue and Organ Development to in Vitro Models
Bioprinting techniques have been flourishing in the field of biofabrication with pronounced
and exponential developments in the past years. Novel biomaterial inks used for the …
and exponential developments in the past years. Novel biomaterial inks used for the …
Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment
The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
Microglial Piezo1 senses Aβ fibril stiffness to restrict Alzheimer's disease
The pathology of Alzheimer's disease (AD) is featured with extracellular amyloid-β (Aβ)
plaques, whose impact on the mechanical properties of the surrounding brain tissues is …
plaques, whose impact on the mechanical properties of the surrounding brain tissues is …
Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo
Collective cell migration is essential for morphogenesis, tissue remodelling and cancer
invasion,. In vivo, groups of cells move in an orchestrated way through tissues. This …
invasion,. In vivo, groups of cells move in an orchestrated way through tissues. This …
[HTML][HTML] Injectable hydrogels in central nervous system: Unique and novel platforms for promoting extracellular matrix remodeling and tissue engineering
Repairing central nervous system (CNS) is difficult due to the inability of neurons to recover
after damage. A clinically acceptable treatment to promote CNS functional recovery and …
after damage. A clinically acceptable treatment to promote CNS functional recovery and …
[HTML][HTML] Advancements in tissue and organ 3D bioprinting: Current techniques, applications, and future perspectives
Abstract 3D bioprinting techniques have emerged as a flexible tool in tissue engineering
and regenerative medicine to fabricate or pattern functional 3D bio-structures with precise …
and regenerative medicine to fabricate or pattern functional 3D bio-structures with precise …
Force spectroscopy of single cells using atomic force microscopy
Physical forces and mechanical properties have critical roles in cellular function, physiology
and disease. Over the past decade, atomic force microscopy (AFM) techniques have …
and disease. Over the past decade, atomic force microscopy (AFM) techniques have …