Moving beyond the glial scar for spinal cord repair

EJ Bradbury, ER Burnside - Nature communications, 2019 - nature.com
Traumatic spinal cord injury results in severe and irreversible loss of function. The injury
triggers a complex cascade of inflammatory and pathological processes, culminating in …

Atomic force microscopy-based mechanobiology

M Krieg, G Fläschner, D Alsteens, BM Gaub… - Nature Reviews …, 2019 - nature.com
Mechanobiology emerges at the crossroads of medicine, biology, biophysics and
engineering and describes how the responses of proteins, cells, tissues and organs to …

[HTML][HTML] Mechanics in the nervous system: from development to disease

EK Pillai, K Franze - Neuron, 2024 - cell.com
Physical forces are ubiquitous in biological processes across scales and diverse contexts.
This review highlights the significance of mechanical forces in nervous system development …

Bioprinting: From Tissue and Organ Development to in Vitro Models

C Mota, S Camarero-Espinosa, MB Baker… - Chemical …, 2020 - ACS Publications
Bioprinting techniques have been flourishing in the field of biofabrication with pronounced
and exponential developments in the past years. Novel biomaterial inks used for the …

Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment

G Huang, F Li, X Zhao, Y Ma, Y Li, M Lin, G **… - Chemical …, 2017 - ACS Publications
The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Microglial Piezo1 senses Aβ fibril stiffness to restrict Alzheimer's disease

J Hu, Q Chen, H Zhu, L Hou, W Liu, Q Yang, H Shen… - Neuron, 2023 - cell.com
The pathology of Alzheimer's disease (AD) is featured with extracellular amyloid-β (Aβ)
plaques, whose impact on the mechanical properties of the surrounding brain tissues is …

Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo

EH Barriga, K Franze, G Charras, R Mayor - Nature, 2018 - nature.com
Collective cell migration is essential for morphogenesis, tissue remodelling and cancer
invasion,. In vivo, groups of cells move in an orchestrated way through tissues. This …

[HTML][HTML] Injectable hydrogels in central nervous system: Unique and novel platforms for promoting extracellular matrix remodeling and tissue engineering

E Hasanzadeh, A Seifalian, A Mellati, J Saremi… - Materials Today Bio, 2023 - Elsevier
Repairing central nervous system (CNS) is difficult due to the inability of neurons to recover
after damage. A clinically acceptable treatment to promote CNS functional recovery and …

[HTML][HTML] Advancements in tissue and organ 3D bioprinting: Current techniques, applications, and future perspectives

M Mirshafiei, H Rashedi, F Yazdian, A Rahdar… - Materials & Design, 2024 - Elsevier
Abstract 3D bioprinting techniques have emerged as a flexible tool in tissue engineering
and regenerative medicine to fabricate or pattern functional 3D bio-structures with precise …

Force spectroscopy of single cells using atomic force microscopy

A Viljoen, M Mathelié-Guinlet, A Ray… - Nature Reviews …, 2021 - nature.com
Physical forces and mechanical properties have critical roles in cellular function, physiology
and disease. Over the past decade, atomic force microscopy (AFM) techniques have …