Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …

Traumatic brain injury (TBI) remains one of the most fatal and debilitating conditions in the
world. Current clinical management in severe TBI patients is mainly concerned with …

Background Clinical prediction models should be validated before implementation in clinical
practice. But is favorable performance at internal validation or one external validation …

Background The indications for intracranial pressure (ICP) monitoring in patients with acute
brain injury and the effects of ICP on patients' outcomes are uncertain. The aims of this study …

Purpose To provide clinical practice recommendations and generate a research agenda on
mechanical ventilation and respiratory support in patients with acute brain injury (ABI) …

Purpose Contemporary trauma resuscitation prioritizes control of bleeding and uses major
haemorrhage protocols (MHPs) to prevent and treat coagulopathy. We aimed to determine …

Background Serum biomarkers may inform and improve care in traumatic brain injury (TBI).
We aimed to correlate serum biomarkers with clinical severity, care path and imaging …

Background Several studies have reported an association between serum biomarker values
and functional outcome following traumatic brain injury. We aimed to examine the …

Background Traumatic brain injury (TBI) is increasingly recognised as being responsible for
a substantial proportion of the global burden of disease. Neurosurgical interventions are an …

Importance Fluid therapy is an important component of care for patients with traumatic brain
injury, but whether it modulates clinical outcomes remains unclear. Objective To determine …