Traumatic brain injury: progress and challenges in prevention, clinical care, and research
Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …
neurological disorders, and poses a substantial public health burden. TBI is increasingly …
Management of moderate to severe traumatic brain injury: an update for the intensivist
Traumatic brain injury (TBI) remains one of the most fatal and debilitating conditions in the
world. Current clinical management in severe TBI patients is mainly concerned with …
world. Current clinical management in severe TBI patients is mainly concerned with …
There is no such thing as a validated prediction model
Background Clinical prediction models should be validated before implementation in clinical
practice. But is favorable performance at internal validation or one external validation …
practice. But is favorable performance at internal validation or one external validation …
Mechanical ventilation in patients with acute brain injury: recommendations of the European Society of Intensive Care Medicine consensus
Purpose To provide clinical practice recommendations and generate a research agenda on
mechanical ventilation and respiratory support in patients with acute brain injury (ABI) …
mechanical ventilation and respiratory support in patients with acute brain injury (ABI) …
Intracranial pressure monitoring in patients with acute brain injury in the intensive care unit (SYNAPSE-ICU): an international, prospective observational cohort study
Background The indications for intracranial pressure (ICP) monitoring in patients with acute
brain injury and the effects of ICP on patients' outcomes are uncertain. The aims of this study …
brain injury and the effects of ICP on patients' outcomes are uncertain. The aims of this study …
Viscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled trial
K Baksaas-Aasen, LS Gall, J Stensballe… - Intensive care …, 2021 - Springer
Purpose Contemporary trauma resuscitation prioritizes control of bleeding and uses major
haemorrhage protocols (MHPs) to prevent and treat coagulopathy. We aimed to determine …
haemorrhage protocols (MHPs) to prevent and treat coagulopathy. We aimed to determine …
Blood biomarkers on admission in acute traumatic brain injury: relations to severity, CT findings and care path in the CENTER-TBI study
Background Serum biomarkers may inform and improve care in traumatic brain injury (TBI).
We aimed to correlate serum biomarkers with clinical severity, care path and imaging …
We aimed to correlate serum biomarkers with clinical severity, care path and imaging …
Casemix, management, and mortality of patients receiving emergency neurosurgery for traumatic brain injury in the Global Neurotrauma Outcomes Study: a …
Background Traumatic brain injury (TBI) is increasingly recognised as being responsible for
a substantial proportion of the global burden of disease. Neurosurgical interventions are an …
a substantial proportion of the global burden of disease. Neurosurgical interventions are an …
Effect of continuous infusion of hypertonic saline vs standard care on 6-month neurological outcomes in patients with traumatic brain injury: the COBI randomized …
Importance Fluid therapy is an important component of care for patients with traumatic brain
injury, but whether it modulates clinical outcomes remains unclear. Objective To determine …
injury, but whether it modulates clinical outcomes remains unclear. Objective To determine …
Surgery versus conservative treatment for traumatic acute subdural haematoma: a prospective, multicentre, observational, comparative effectiveness study
Background Despite being well established, acute surgery in traumatic acute subdural
haematoma is based on low-grade evidence. We aimed to compare the effectiveness of a …
haematoma is based on low-grade evidence. We aimed to compare the effectiveness of a …