Epigenetic regulation in hematopoiesis and its implications in the targeted therapy of hematologic malignancies

A Zhao, H Zhou, J Yang, M Li, T Niu - Signal transduction and targeted …, 2023 - nature.com
Hematologic malignancies are one of the most common cancers, and the incidence has
been rising in recent decades. The clinical and molecular features of hematologic …

MicroRNAs as regulatory elements in immune system logic

A Mehta, D Baltimore - Nature Reviews Immunology, 2016 - nature.com
MicroRNAs (miRNAs) are crucial post-transcriptional regulators of haematopoietic cell fate
decisions. They act by negatively regulating the expression of key immune development …

MicroRNA as biomarkers and diagnostics

J Wang, J Chen, S Sen - Journal of cellular physiology, 2016 - Wiley Online Library
MicroRNAs (miRNAs) are a group of small non‐coding RNAs that are involved in regulating
a range of developmental and physiological processes; their dysregulation has been …

Therapeutic targeting of microRNAs: current status and future challenges

Z Li, TM Rana - Nature reviews Drug discovery, 2014 - nature.com
MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that have crucial
roles in regulating gene expression. Increasing evidence supports a role for miRNAs in …

MicroRNA: biogenesis, function and role in cancer

LA MacFarlane, PR Murphy - Current genomics, 2010 - ingentaconnect.com
MicroRNAs are small, highly conserved non-coding RNA molecules involved in the
regulation of gene expression. MicroRNAs are transcribed by RNA polymerases II and III …

MicroRNAs in human cancer

TA Farazi, JI Hoell, P Morozov, T Tuschl - MicroRNA cancer regulation …, 2013 - Springer
Mature microRNAs (miRNAs) are single-stranded RNA molecules of 20–23-nucleotide (nt)
length that control gene expression in many cellular processes. These molecules typically …

MicroRNAs in liver disease

G Szabo, S Bala - Nature reviews Gastroenterology & hepatology, 2013 - nature.com
Small, noncoding microRNAs (miRNAs) regulate diverse biological functions in the liver and
increasing evidence suggests that they have a role in liver pathology. This Review …

MicroRNAs: biomarkers, diagnostics, and therapeutics

W Huang - Bioinformatics in MicroRNA research, 2017 - Springer
MicroRNAs (miRNAs) are small noncoding RNAs (21–23 nucleotides in length) that regulate
gene expression at translational or posttranslational levels. The major regulatory …

miRNAs in pancreatic cancer progression and metastasis

ETY Mok, JL Chitty, TR Cox - Clinical & experimental metastasis, 2024 - Springer
Small non-coding RNA or microRNA (miRNA) are critical regulators of eukaryotic cells.
Dysregulation of miRNA expression and function has been linked to a variety of diseases …

MicroRNA expression profiles classify human cancers

J Lu, G Getz, EA Miska, E Alvarez-Saavedra, J Lamb… - nature, 2005 - nature.com
Recent work has revealed the existence of a class of small non-coding RNA species, known
as microRNAs (miRNAs), which have critical functions across various biological processes …