[HTML][HTML] Genetic insights into the neurobiology of anxiety

MK Koskinen, I Hovatta - Trends in Neurosciences, 2023 - cell.com
Anxiety and fear are evolutionarily conserved emotions that increase the likelihood of an
organism surviving threatening situations. Anxiety and vigilance states are regulated by …

[BOOK][B] RNA, the epicenter of genetic information

J Mattick, P Amaral - 2023 - library.oapen.org
The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Isoform-level transcriptome-wide association uncovers genetic risk mechanisms for neuropsychiatric disorders in the human brain

A Bhattacharya, DD Vo, C Jops, M Kim, C Wen… - Nature Genetics, 2023 - nature.com
Methods integrating genetics with transcriptomic reference panels prioritize risk genes and
mechanisms at only a fraction of trait-associated genetic loci, due in part to an overreliance …

Genetic contributions to anxiety disorders: where we are and where we are heading

H Ask, R Cheesman, ES Jami, DF Levey… - Psychological …, 2021 - cambridge.org
Anxiety disorders are among the most common psychiatric disorders worldwide. They often
onset early in life, with symptoms and consequences that can persist for decades. This …

Psychiatric disorders and type 2 diabetes mellitus: a bidirectional Mendelian randomization

H Tao, S Fan, T Zhu, L You, D Zheng… - European Journal of …, 2023 - Wiley Online Library
Background Extensive observational evidence put forward the association between
psychiatric disorders and type 2 diabetes mellitus (T2DM). However, causal relationships …

Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications

RBTM Sterenborg, I Steinbrenner, Y Li… - Nature …, 2024 - nature.com
To date only a fraction of the genetic footprint of thyroid function has been clarified. We
report a genome-wide association study meta-analysis of thyroid function in up to 271,040 …

Mendelian randomization analyses reveal causal relationships between brain functional networks and risk of psychiatric disorders

C Mu, X Dang, XJ Luo - Nature human behaviour, 2024 - nature.com
Dysfunction of brain resting-state functional networks has been widely reported in
psychiatric disorders. However, the causal relationships between brain resting-state …

Cognitive processing speed and accuracy are intrinsically different in genetic architecture and brain phenotypes

M Li, X Dang, Y Chen, Z Chen, X Xu, Z Zhao… - Nature …, 2024 - nature.com
Since the birth of cognitive science, researchers have used reaction time and accuracy to
measure cognitive ability. Although recognition of these two measures is often based on …

Mental personality disorders: Current state of the problem statement

L Spytska - Kyiv journal of modern psychology and psychotherapy, 2023 - mpp-journal.com
The stages of personality formation are regulated by qualitative and quantitative changes in
a person's physiological development and the consequences of his interaction with the …