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Chemical reprogramming for cell fate manipulation: methods, applications, and perspectives
J Wang, S Sun, H Deng - Cell Stem Cell, 2023 - cell.com
Chemical reprogramming offers an unprecedented opportunity to control somatic cell fate
and generate desired cell types including pluripotent stem cells for applications in …
and generate desired cell types including pluripotent stem cells for applications in …
[HTML][HTML] Advances and applications of biomimetic biomaterials for endogenous skin regeneration
M Wang, Y Hong, X Fu, X Sun - Bioactive Materials, 2024 - Elsevier
Endogenous regeneration is becoming an increasingly important strategy for wound healing
as it facilitates skin's own regenerative potential for self-healing, thereby avoiding the risks of …
as it facilitates skin's own regenerative potential for self-healing, thereby avoiding the risks of …
Chemical reprogramming of human somatic cells to pluripotent stem cells
Cellular reprogramming can manipulate the identity of cells to generate the desired cell
types,–. The use of cell intrinsic components, including oocyte cytoplasm and transcription …
types,–. The use of cell intrinsic components, including oocyte cytoplasm and transcription …
Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming
S Liuyang, G Wang, Y Wang, H He, Y Lyu, L Cheng… - Cell Stem Cell, 2023 - cell.com
We recently demonstrated the chemical reprogramming of human somatic cells to
pluripotent stem cells (hCiPSCs), which provides a robust approach for cell fate …
pluripotent stem cells (hCiPSCs), which provides a robust approach for cell fate …
Glis1 facilitates induction of pluripotency via an epigenome–metabolome–epigenome signalling cascade
Somatic cell reprogramming provides insight into basic principles of cell fate determination,
which remain poorly understood. Here we show that the transcription factor Glis1 induces …
which remain poorly understood. Here we show that the transcription factor Glis1 induces …
Single-cell RNA-seq reveals dynamic early embryonic-like programs during chemical reprogramming
Chemical reprogramming provides a powerful platform for exploring the molecular dynamics
that lead to pluripotency. Although previous studies have uncovered an intermediate …
that lead to pluripotency. Although previous studies have uncovered an intermediate …
In vivo chemical reprogramming of astrocytes into neurons
Y Ma, H **e, X Du, L Wang, X **, Q Zhang, Y Han… - Cell discovery, 2021 - nature.com
In mammals, many organs lack robust regenerative abilities. Lost cells in impaired tissue
could potentially be compensated by converting nearby cells in situ through in vivo …
could potentially be compensated by converting nearby cells in situ through in vivo …
Targeting the vascular and perivascular niches as a regenerative therapy for lung and liver fibrosis
The regenerative capacity of lung and liver is sometimes impaired by chronic or
overwhelming injury. Orthotopic transplantation of parenchymal stem cells to damaged …
overwhelming injury. Orthotopic transplantation of parenchymal stem cells to damaged …
Defining human pluripotency
Human pluripotent stem cells harbor the capacity to differentiate into cells from the three
embryonic germ layers, and this ability grants them a central role in modeling human …
embryonic germ layers, and this ability grants them a central role in modeling human …
The primitive endoderm supports lineage plasticity to enable regulative development
M Linneberg-Agerholm, AC Sell, A Redó-Riveiro… - Cell, 2024 - cell.com
Mammalian blastocyst formation involves the specification of the trophectoderm followed by
the differentiation of the inner cell mass into embryonic epiblast and extra-embryonic …
the differentiation of the inner cell mass into embryonic epiblast and extra-embryonic …