The integrity of our genetic material is under constant attack from numerous endogenous
and exogenous agents. The consequences of a defective DNA damage response are well …

Eukaryotic chromatin is kept flexible and dynamic to respond to environmental, metabolic,
and developmental cues through the action of a family of so-called “nucleosome …

Abstract Background Deregulated circular RNAs (circRNAs) are associated with the
development of cancer and therapy resistance. However, functional research of circRNAs …

Alternative lengthening of telomeres (ALT) is a telomerase-independent but recombination-
dependent pathway that maintains telomeres. Here, we describe an assay to visualize ALT …

Abstract ARID1A, SWI/SNF chromatin remodeling complex subunit, is a recently identified
tumor suppressor that is mutated in a broad spectrum of human cancers. Thus, it is of …

Recruitment of DNA repair proteins to DNA damage sites is a critical step for DNA repair.
Post-translational modifications of proteins at DNA damage sites serve as DNA damage …

DNA damage is linked to multiple human diseases, such as cancer, neurodegeneration, and
aging. Little is known about the role of chromatin accessibility in DNA repair. Here, we find …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …

Alternative lengthening of telomeres (ALT) is a homology-directed repair (HDR) mechanism
of telomere elongation that controls proliferation in subsets of aggressive cancer. Recent …

How chromatin shapes pathways that promote genome–epigenome integrity in response to
DNA damage is an issue of crucial importance. We report that human bromodomain (BRD) …