Genome-wide cancer mutation analyses are revealing an extensive landscape of functional
mutations within the noncoding genome, with profound effects on the expression of long …

Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …

To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-
genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence …

Aspirin (acetylsalicylic acid) has become one of the most commonly used drugs, given its
role as an analgesic, antipyretic and agent for cardiovascular prophylaxis. Several decades …

Sporadic colorectal cancer (CRC) is a somatic genetic disease in which pathogenesis is
influenced by the local colonic environment and the patient's genetic background …

Enhancer elements function as the logic gates of the genetic regulatory circuitry. One of their
most important functions is the integration of extracellular signals with intracellular cell fate …

Genome-wide association studies have identified many variants that each affects multiple
traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders …

Many individuals with multiple or large colorectal adenomas or early-onset colorectal cancer
(CRC) have no detectable germline mutations in the known cancer predisposition genes …

BACKGROUND: A high circulating concentration of interleukin 6 is associated with
increased risk of coronary heart disease. Blockade of the interleukin-6 receptor (IL6R) with a …

The functional roles of SNPs within the 8q24 gene desert in the cancer phenotype are not
yet well understood. Here, we report that CCAT2, a novel long noncoding RNA transcript …