Molecular dynamics simulations in drug discovery and pharmaceutical development
Molecular dynamics (MD) simulations have become increasingly useful in the modern drug
development process. In this review, we give a broad overview of the current application …
development process. In this review, we give a broad overview of the current application …
Pharmaceutical solvates, hydrates and amorphous forms: A special emphasis on cocrystals
Active pharmaceutical ingredients (APIs) may exist in various solid forms, which can lead to
differences in the intermolecular interactions, affecting the internal energy and enthalpy, and …
differences in the intermolecular interactions, affecting the internal energy and enthalpy, and …
Recent advances in co-amorphous drug formulations
Co-amorphous drug delivery systems have recently gained considerable interest in the
pharmaceutical field because of their potential to improve oral bioavailability of poorly water …
pharmaceutical field because of their potential to improve oral bioavailability of poorly water …
Manufacturing of solid dispersions of poorly water soluble drugs by spray drying: formulation and process considerations
Spray drying is an efficient technology for solid dispersion manufacturing since it allows
extreme rapid solvent evaporation leading to fast transformation of an API-carrier solution to …
extreme rapid solvent evaporation leading to fast transformation of an API-carrier solution to …
Co-amorphous solid dispersions for solubility and absorption improvement of drugs: Composition, preparation, characterization and formulations for oral delivery
The amorphous solid state offers an improved apparent solubility and dissolution rate.
However, due to thermodynamic instability and recrystallization tendencies during …
However, due to thermodynamic instability and recrystallization tendencies during …
Emerging trends in the stabilization of amorphous drugs
R Laitinen, K Löbmann, CJ Strachan… - International journal of …, 2013 - Elsevier
The number of active pharmaceutical substances having high therapeutic potential but low
water solubility is constantly increasing, making it difficult to formulate these compounds as …
water solubility is constantly increasing, making it difficult to formulate these compounds as …
Engineering cocrystals of poorly water-soluble drugs to enhance dissolution in aqueous medium
Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor
aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and …
aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and …
Use of pharmaceutical salts and cocrystals to address the issue of poor solubility
DP Elder, R Holm, HL De Diego - International journal of pharmaceutics, 2013 - Elsevier
Salt and cocrystal formation are the most commonly used method of increasing solubility
and dissolution rate of pharmaceutical compounds, and are of particular interest for …
and dissolution rate of pharmaceutical compounds, and are of particular interest for …
[HTML][HTML] Advances in coamorphous drug delivery systems
Q Shi, SM Moinuddin, T Cai - Acta pharmaceutica sinica B, 2019 - Elsevier
In recent years, the coamorphous drug delivery system has been established as a promising
formulation approach for delivering poorly water-soluble drugs. The coamorphous solid is a …
formulation approach for delivering poorly water-soluble drugs. The coamorphous solid is a …
Amino acids as co-amorphous stabilizers for poorly water soluble drugs–Part 1: Preparation, stability and dissolution enhancement
Poor aqueous solubility of an active pharmaceutical ingredient (API) is one of the most
pressing problems in pharmaceutical research and development because up to 90% of new …
pressing problems in pharmaceutical research and development because up to 90% of new …