Generation of nanoscopic membrane curvature for membrane trafficking

MM Kozlov, JW Taraska - Nature reviews Molecular cell biology, 2023 - nature.com
Curved membranes are key features of intracellular organelles, and their generation
involves dynamic protein complexes. Here we describe the fundamental mechanisms such …

Biomolecular condensates in contact with membranes

A Mangiarotti, R Dimova - Annual Review of Biophysics, 2024 - annualreviews.org
Biomolecular condensates are highly versatile membraneless organelles involved in a
plethora of cellular processes. Recent years have witnessed growing evidence of the …

Stress granules plug and stabilize damaged endolysosomal membranes

C Bussi, A Mangiarotti, C Vanhille-Campos, B Aylan… - Nature, 2023 - nature.com
Endomembrane damage represents a form of stress that is detrimental for eukaryotic cells,.
To cope with this threat, cells possess mechanisms that repair the damage and restore …

Wetting and complex remodeling of membranes by biomolecular condensates

A Mangiarotti, N Chen, Z Zhao, R Lipowsky… - Nature …, 2023 - nature.com
Cells compartmentalize parts of their interiors into liquid-like condensates, which can be
reconstituted in vitro. Although these condensates interact with membrane-bound …

Kinetic control of shape deformations and membrane phase separation inside giant vesicles

WC Su, JCS Ho, DL Gettel, AT Rowland, CD Keating… - Nature Chemistry, 2024 - nature.com
A variety of cellular processes use liquid–liquid phase separation (LLPS) to create functional
levels of organization, but the kinetic pathways by which it proceeds remain incompletely …

Biomolecular condensates modulate membrane lipid packing and hydration

A Mangiarotti, M Siri, NW Tam, Z Zhao… - Nature …, 2023 - nature.com
Membrane wetting by biomolecular condensates recently emerged as a key phenomenon in
cell biology, playing an important role in a diverse range of processes across different …

Different pathways for engulfment and endocytosis of liquid droplets by nanovesicles

R Ghosh, V Satarifard, R Lipowsky - Nature Communications, 2023 - nature.com
During endocytosis of nanoparticles by cells, the cellular membranes engulf the particles,
thereby forming a closed membrane neck that subsequently undergoes fission. For solid …

Advances in giant unilamellar vesicle preparation techniques and applications

KS Nair, H Bajaj - Advances in Colloid and Interface Science, 2023 - Elsevier
Giant unilamellar vesicles (GUVs) are versatile and promising cell-sized bio-membrane
mimetic platforms. Their applications range from understanding and quantifying membrane …

Membrane nanotubes transform into double-membrane sheets at condensate droplets

Z Zhao, V Satarifard, R Lipowsky, R Dimova - Proceedings of the National …, 2024 - pnas.org
Cellular membranes exhibit a multitude of highly curved morphologies such as buds,
nanotubes, cisterna-like sheets defining the outlines of organelles. Here, we mimic cell …

Increased efficiency of charge-mediated fusion in polymer/lipid hybrid membranes

N Marušič, L Otrin, J Rauchhaus, Z Zhao… - Proceedings of the …, 2022 - pnas.org
Due to their augmented properties, biomimetic polymer/lipid hybrid compartments are a
promising substitute for natural liposomes in multiple applications, but the protein-free fusion …