If fully stretched out, a typical bacterial chromosome would be nearly 1 mm long,
approximately 1,000 times the length of a cell. Not only must cells massively compact their …

Bacterial physiology is a branch of biology that aims to understand overarching principles of
cellular reproduction. Many important issues in bacterial physiology are inherently …

As in eukaryotes, bacterial genomes are not randomly folded. Bacterial genetic information
is generally carried on a circular chromosome with a single origin of replication from which …

Chromosomes of a broad range of species, from bacteria to mammals, are structured by
large topological domains whose precise functional roles and regulatory mechanisms …

Transcription generates local topological and mechanical constraints on the DNA fiber,
leading to the generation of supercoiled chromosome domains in bacteria. However, the …

How genomes are organized within cells and how the 3D architecture of a genome
influences cellular functions are significant questions in biology. A bacterial genomic DNA …

The Escherichia coli SMC complex, MukBEF, forms clusters of molecules that interact with
the decatenase topisomerase IV and which are normally associated with the chromosome …

Precise and rapid DNA segregation is required for proper inheritance of genetic material. In
most bacteria and archaea, this process is assured by a broadly conserved mitotic-like …

DNA supercoiling is central to many fundamental processes of living organisms. Its average
level along the chromosome and over time reflects the dynamic equilibrium of opposite …

Higher-order chromosome folding and segregation are tightly regulated in all domains of
life. In bacteria, details on nucleoid organization regulatory mechanisms and function remain …