With recent rapid progress in research on aging, there is increasing evidence that many
features commonly considered to be mechanisms or drivers of aging in fact represent …

With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …

Lifespan varies within and across species, but the general principles of its control remain
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …

Exercise training prevents age‐related decline in muscle function. Targeting epigenetic
aging is a promising actionable mechanism and late‐life exercise mitigates epigenetic aging …

In the last decade epigenetics has come to the fore as a discipline which is central to
biogerontology. Age associated epigenetic changes are routinely linked with pathologies …

The extracellular matrix (ECM), composed of interlinked proteins outside of cells, is an
important component of the human body that helps maintain tissue architecture and cellular …

Individuals with psychiatric disorders are at increased risk of age-related diseases and early
mortality. Recent studies demonstrate that this link between mental health and aging is …

Metabolomics, the global profiling of small molecules in the body, has emerged as a
promising analytical approach for assessing molecular changes associated with ageing at …

Age-related changes in DNA methylation (DNAm) form the basis of the most robust
predictors of age—epigenetic clocks—but a clear mechanistic understanding of exactly …

Based on the ideas of RA Fisher, neoDarwinism came to dominate evolutionary science in
the first half of the wentieth entury, and within that perspective aging could never be an …