Alleles that introgress between species can influence the evolutionary and ecological fate of
species exposed to novel environments. Hybrid offspring of different species are often unfit …

Germline variation and somatic mutation are intricately connected and together shape
human traits and disease risks. Germline variants are present from conception, but they vary …

Haplotype phasing is the estimation of haplotypes from genotype data. We present a fast,
accurate, and memory-efficient haplotype phasing method that scales to large-scale SNP …

Motivation Linkage disequilibrium (LD) decay is of great interest in population genetic
studies. However, no tool is available now to do LD decay analysis from variant call format …

The African continent is regarded as the cradle of modern humans and African genomes
contain more genetic variation than those from any other continent, yet only a fraction of the …

Signals of local adaptation have been found in many plants and animals, highlighting the
heterogeneity in the distribution of adaptive genetic variation throughout species ranges. In …

Speciation, the evolution of reproductive isolation among populations, is continuous,
complex, and involves multiple, interacting barriers. Until it is complete, the effects of this …

Rapid global climate change is posing a substantial threat to biodiversity. The assessment of
population vulnerability and adaptive capacity under climate change is crucial for informing …

In Africa, most rapid diagnostic tests (RDTs) for falciparum malaria recognize histidine-rich
protein 2 antigen. Plasmodium falciparum parasites lacking histidine-rich protein 2 (pfhrp2) …

In the mosquito–human life cycle, the six species of malaria parasites infecting humans
(Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale wallickeri, Plasmodium …