Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …

Engineered gene drives—the process of stimulating the biased inheritance of specific genes—
have the potential to enable the spread of desirable genes throughout wild populations or to …

Recently, the Vaccines to Vaccinate (v2V) initiative was reconfigured into the Partnership for
Dengue Control (PDC), a multi-sponsored and independent initiative. This redirection is …

CRISPR/Cas9 gene drive (CGD) promises to be a highly adaptable approach for spreading
genetically engineered alleles throughout a species, even if those alleles impair …

Recent reports have suggested that self-propagating CRISPR-based gene drive systems
are unlikely to efficiently invade wild populations due to drive-resistant alleles that prevent …

The alteration of wild populations has been discussed as a solution to a number of
humanity's most pressing ecological and public health concerns. Enabled by the recent …

Gene drive organisms (GDOs), whose genomes have been genetically engineered to
spread a desired allele through a population, have the potential to transform the way …

Synthetic gene drive systems possess enormous potential to replace, alter, or suppress wild
populations of significant disease vectors and crop pests; however, their utility in diverse …

Wolbachia are maternally inherited bacteria that infect arthropod species worldwide and are
deployed in vector control to curb arboviral spread using cytoplasmic incompatibility (CI). CI …

There is great interest in being able to spread beneficial traits throughout wild populations in
ways that are self-sustaining. Here, we describe a chromosomal selfish genetic element …