A genomic perspective on HLA evolution
Several decades of research have convincingly shown that classical human leukocyte
antigen (HLA) loci bear signatures of natural selection. Despite this conclusion, many …
antigen (HLA) loci bear signatures of natural selection. Despite this conclusion, many …
Therapeutic DNA vaccines against HPV-related malignancies: promising leads from clinical trials
J Tang, M Li, C Zhao, D Shen, L Liu, X Zhang, L Wei - Viruses, 2022 - mdpi.com
In 2014 and 2021, two nucleic-acid vaccine candidates named MAV E2 and VGX-3100
completed phase III clinical trials in Mexico and US, respectively, for patients with human …
completed phase III clinical trials in Mexico and US, respectively, for patients with human …
Immunoinformatics‐aided identification of T cell and B cell epitopes in the surface glycoprotein of 2019‐nCoV
V Baruah, S Bose - Journal of medical virology, 2020 - Wiley Online Library
Abstract The 2019 novel coronavirus (2019‐nCoV) outbreak has caused a large number of
deaths with thousands of confirmed cases worldwide, especially in East Asia. This study …
deaths with thousands of confirmed cases worldwide, especially in East Asia. This study …
Binding affinities of 438 HLA proteins to complete proteomes of seven pandemic viruses and distributions of strongest and weakest HLA peptide binders in …
We report detailed peptide‐binding affinities between 438 HLA Class I and Class II proteins
and complete proteomes of seven pandemic human viruses, including coronaviruses …
and complete proteomes of seven pandemic human viruses, including coronaviruses …
An HLA map of the world: A comparison of HLA frequencies in 200 worldwide populations reveals diverse patterns for class I and class II
HLA frequencies show widespread variation across human populations. Demographic
factors as well as selection are thought to have shaped HLA variation across continents. In …
factors as well as selection are thought to have shaped HLA variation across continents. In …
HLA heterozygote advantage against HIV-1 is driven by quantitative and qualitative differences in HLA allele-specific peptide presentation
Pathogen-mediated balancing selection is regarded as a key driver of host immunogenetic
diversity. A hallmark for balancing selection in humans is the heterozygote advantage at …
diversity. A hallmark for balancing selection in humans is the heterozygote advantage at …
The most frequent HLA alleles around the world: a fundamental synopsis
A Sanchez-Mazas, JM Nunes, EA DOMINGUEZ… - Best Practice & …, 2024 - Elsevier
A comprehensive knowledge of human leukocyte antigen (HLA) molecular variation
worldwide is essential in human population genetics research and disease association …
worldwide is essential in human population genetics research and disease association …
Vaccine design based on 16 epitopes of SARS‐CoV‐2 spike protein
J He, F Huang, J Zhang, Q Chen… - Journal of medical …, 2021 - Wiley Online Library
The global outbreak of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)
urgently requires an effective vaccine for prevention. In this study, 66 epitopes containing …
urgently requires an effective vaccine for prevention. In this study, 66 epitopes containing …
A review of HLA allele and SNP associations with highly prevalent infectious diseases in human populations
A Sanchez-Mazas - Swiss medical weekly, 2020 - smw.ch
Human leucocyte antigen (HLA) alleles and single nucleotide polymorphisms (SNPs) lying
in the HLA region are known to be associated with several infectious diseases among which …
in the HLA region are known to be associated with several infectious diseases among which …
The mutational landscape of SARS-CoV-2 variants diversifies T cell targets in an HLA-supertype-dependent manner
The rapid, global dispersion of SARS-CoV-2 has led to the emergence of a diverse range of
variants. Here, we describe how the mutational landscape of SARS-CoV-2 has shaped HLA …
variants. Here, we describe how the mutational landscape of SARS-CoV-2 has shaped HLA …