The concept of 'idiopathic'Parkinson's disease (PD) as a single entity has been challenged
with the identification of several clinical subtypes, pathogenic genes and putative causative …

Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent
neurodegenerative diseases, affecting millions and costing billions each year in the United …

SYNOPSIS (1 paragraph): Parkinson's disease (PD) is a complex age-related
neurodegenerative disease associated with dopamine deficiency and both motor and …

The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely
vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary …

Ageing is an inevitable event in the lifecycle of all organisms, characterized by progressive
physiological deterioration and increased vulnerability to death. Ageing has also been …

We developed an endophenotype disease module-based methodology for Alzheimer's
disease (AD) drug repurposing and identified sildenafil as a potential disease risk modifier …

The Alzheimer's disease (AD) afflicted brain is neuropathologically defined by extracellular
amyloid-β (Aβ) plaques and intraneuronal neurofibrillary tangles composed of …

There is no consensus on the exact role of the adaptive immune system in Parkinson's
disease pathogenesis, although there is increasing evidence that it is somehow involved …

Mitochondria-associated endoplasmic reticulum membranes (MAMs) are dynamic
membrane coupling regions formed by the coupling of the mitochondrial outer membrane …

Many potential immune therapeutic targets are similarly affected in adult-onset
neurodegenerative diseases, such as Alzheimer's (AD) disease, Parkinson's disease (PD) …