Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

Cell type-and differentiation-specific gene expression is precisely controlled by genomic non-
coding regulatory elements (NCREs), which include promoters, enhancers, silencers and …

Small cell lung cancer (SCLC) exists broadly in four molecular subtypes: ASCL1,
NEUROD1, POU2F3 and Inflammatory. Initially, SCLC subtypes were thought to be mutually …

Epigenetic reprogramming is a critical process of pathological gene induction during cardiac
hypertrophy and remodeling, but the underlying regulatory mechanisms remain to be …

Histone modifications and chromatin-associated protein complexes are crucially involved in
the control of gene expression, supervising cell fate decisions and differentiation. Many …

The Polycomb group (PcG) of proteins defines a subset of factors that physically associate
and function to maintain the positional identity of cells from the embryo to adult stages. PcG …

Our understanding of the detailed molecular mechanisms underpinning adaptation is still
poor. One example for which mechanistic understanding of regulation has converged with …

Neuronal activity-induced gene expression modulates the function and plasticity of the
nervous system. It is unknown whether and to what extent neuronal activity may trigger …

Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …

Mononucleosomes, the basic building blocks of chromatin, contain two copies of each core
histone. The associated posttranslational modifications regulate essential chromatin …