Fibrosis is characterized by the excessive production of collagen and other extracellular
matrix (ECM) components and represents a leading cause of morbidity and mortality …

Accurately identifying cell-populations is paramount to the quality of downstream analyses
and overall interpretations of single-cell RNA-seq (scRNA-seq) datasets but remains a …

Background Adoptive transfer of tumor-infiltrating lymphocytes (TIL) fails to consistently elicit
tumor rejection. Manipulation of intrinsic factors that inhibit T cell effector function and …

A system-level understanding of the regulation and coordination mechanisms of gene
expression is essential for studying the complexity of biological processes in health and …

Epithelial-mesenchymal transition (EMT) is well established as playing a crucial role in
cancer progression and being a potential therapeutic target. To elucidate the gene …

Translation of mRNAs is a fundamental process that occurs in all cell types of multicellular
organisms. Conventionally, it has been considered a default step in gene expression …

The toll-like receptor 5 (TLR5) agonist, CBLB502/Entolimod, is a peptide derived from
bacterial flagellin and has been shown to protect against radiation-induced tissue damage …

Vitamin D, a fat-soluble vitamin, plays a critical role in calcium homeostasis, the immune
system, and normal development. Many epidemiological cohort studies globally have found …

Background & Aims Tight junctions in the liver are essential to maintain the blood-biliary
barrier, however, the functional contribution of individual tight junction proteins to barrier and …

Gliomas are highly heterogeneous and aggressive. Malignant cells in gliomas can contact
normal neurons through a synapse-like structure (called neuron-to-glioma synapse, NGS) to …