Biological mass spectrometry (MS) encompasses a range of methods for characterizing
proteins and other biomolecules. MS is uniquely powerful for the structural analysis of …

The eukaryotic cell is compartmentalized into subcellular niches, including membrane-
bound and membrane-less organelles. Proteins localize to these niches to fulfil their …

Biological processes unfold across broad spatial and temporal dimensions, and
measurement of the underlying molecular world is essential to their understanding …

RNA-binding proteins (RBPs) are key mediators of posttranscriptional gene expression
control. However, the links between cell signaling on the one hand and RBP function on the …

Cellular mRNA-binding proteins (mRBPs) are major posttranscriptional regulators of gene
expression. Although many posttranslational modification sites in mRBPs have been …

In response to exercise, the oxidative capacity of mitochondria within skeletal muscle
increases through the coordinated expression of mitochondrial proteins in a process termed …

The brain extracellular matrix (ECM) is a highly glycosylated environment and plays
important roles in many processes including cell communication, growth factor binding, and …

Chemical or enzymatic biotinylation of proteins is widely used in various studies, and
proximity-dependent biotinylation coupled to mass spectrometry is a powerful approach for …

The internal environment of cells is molecularly crowded, which requires spatial
organization via subcellular compartmentalization. These compartments harbor specific …

The elucidation of the subcellular localization of proteins is very important in order to deeply
understand their functions. In fact, proteins activities are strictly correlated to the cellular …