PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
A Glaviano, ASC Foo, HY Lam, KCH Yap, W Jacot… - Molecular cancer, 2023 - Springer
Abstract The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …
Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease
The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …
177Lu-Dotatate plus long-acting octreotide versus high‑dose long-acting octreotide in patients with midgut neuroendocrine tumours (NETTER-1): final overall survival …
Background The primary analysis of the phase 3 NETTER-1 trial showed significant
improvement in progression-free survival with 177 Lu-Dotatate plus long-acting octreotide …
improvement in progression-free survival with 177 Lu-Dotatate plus long-acting octreotide …
Liver metastases
Liver metastases are commonly detected in a range of malignancies including colorectal
cancer (CRC), pancreatic cancer, melanoma, lung cancer and breast cancer, although CRC …
cancer (CRC), pancreatic cancer, melanoma, lung cancer and breast cancer, although CRC …
Personalized management of pheochromocytoma and paraganglioma
S Nölting, N Bechmann, D Taieb… - Endocrine …, 2022 - academic.oup.com
Pheochromocytomas/paragangliomas are characterized by a unique molecular landscape
that allows their assignment to clusters based on underlying genetic alterations. With around …
that allows their assignment to clusters based on underlying genetic alterations. With around …
[HTML][HTML] Gastroenteropancreatic neuroendocrine neoplasms: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
M Pavel, K Öberg, M Falconi, EP Krenning, A Sundin… - Annals of …, 2020 - Elsevier
Neuroendocrine neoplasms (NENs) arise from the diffuse neuroendocrine cell system and
may occur at many different disease sites. Most frequently, these neoplasms occur in the …
may occur at many different disease sites. Most frequently, these neoplasms occur in the …
Targeting the PI3K pathway in cancer: are we making headway?
F Janku, TA Yap, F Meric-Bernstam - Nature reviews Clinical oncology, 2018 - nature.com
Abstract The PI3K–AKT–mTOR pathway is one of the most frequently dysregulated
pathways in cancer and, consequently, more than 40 compounds that target key …
pathways in cancer and, consequently, more than 40 compounds that target key …
Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States
Importance The incidence and prevalence of neuroendocrine tumors (NETs) are thought to
be rising, but updated epidemiologic data are lacking. Objective To explore the evolving …
be rising, but updated epidemiologic data are lacking. Objective To explore the evolving …
Phase 3 Trial of 177Lu-Dotatate for Midgut Neuroendocrine Tumors
J Strosberg, G El-Haddad, E Wolin… - … England Journal of …, 2017 - Mass Medical Soc
Background Patients with advanced midgut neuroendocrine tumors who have had disease
progression during first-line somatostatin analogue therapy have limited therapeutic options …
progression during first-line somatostatin analogue therapy have limited therapeutic options …
Gastroenteropancreatic neuroendocrine tumors
J Strosberg - The American Cancer Society's Oncology in …, 2018 - Wiley Online Library
Neuroendocrine tumors (NETs) are heterogeneous neoplasms that vary considerably based
on primary site, differentiation, and grade. A minority of NETs are characterized by the ability …
on primary site, differentiation, and grade. A minority of NETs are characterized by the ability …