Persistent DNA double-strand breaks (DSBs) in neurons are an early pathological hallmark
of neurodegenerative diseases including Alzheimer's disease (AD), with the potential to …

Human adenoviruses (HAdV) are classified as DNA tumor viruses due to their potential to
mediate oncogenic transformation in non-permissive mammalian cells and certain human …

During aging, skin homeostasis is essential for maintaining appearance, as well as
biological defense of the human body. In this study, we identified thrombospondin-1 …

Cellular senescence is a hallmark of ageing and it plays a key role in the development of
age-related diseases. Abdominal aortic aneurysm (AAA) is an age related degenerative …

Inadequate remnant volume and regenerative ability of the liver pose life-threatening risks to
patients after partial liver transplantation (PLT) or partial hepatectomy (PHx), while few …

Aging is a natural and inevitable process of organisms. With the intensification of population
aging, research on aging has become a hot topic of global attention. The most obvious …

Down syndrome (DS), the most common genetic cause of intellectual disability, is
associated with lifelong cognitive deficits. However, the mechanisms by which triplication of …

Cell lines derived from fish tissues are resistant to premature senescence under typical
culture conditions. Previously, we demonstrated that fish genomes do not have a p16 …

In response to chemotherapy and radiotherapy, a subset of resistant cancer cells avoids cell
death by entering a stable state known as senescence, characterized by prolonged cell …

Aims: The primary aim of this research was to test the hypothesis that injury or critical illness
is sufficient to cause an acceleration of the ageing process. This hypothesis is to be tested …