The proliferative activity of tumour cells represents an important prognostic marker in the
diagnosis of cancer. One of the methods for assessing the proliferative activity of cells is the …

The eukaryotic cell is compartmentalized into subcellular niches, including membrane-
bound and membrane-less organelles. Proteins localize to these niches to fulfil their …

INTRODUCTION During mitosis, cells compact their chromosomes into dense rod-shaped
structures to ensure their reliable transmission to daughter cells. Our work explores how …

Dividing eukaryotic cells package extremely long chromosomal DNA molecules into discrete
bodies to enable microtubule-mediated transport of one genome copy to each of the newly …

Eukaryotic genomes are partitioned into chromosomes that form compact and spatially well-
separated mechanical bodies during mitosis,,. This enables chromosomes to move …

Next-generation sequencing allows the analysis of genomes, including those representing
disease states. However, the causes of most disorders are multifactorial, and systems-level …

During mitosis, transcription is shut off, chromatin condenses, and most transcription factors
(TFs) are reported to be excluded from chromosomes. How do daughter cells re-establish …

In any biological system with memory, the state of the system depends on its history.
Epigenetic memory maintains gene expression states through cell generations without a …

To maintain genome function and stability, DNA sequence and its organization into
chromatin must be duplicated during cell division. Understanding how entire chromosomes …

Measuring the properties of endogenous cell proteins, such as expression level, subcellular
localization, and turnover rates, on a whole proteome level remains a major challenge in the …