DNA methylation is the most extensively studied mechanism of epigenetic gene regulation.
Increasing evidence indicates that DNA methylation is labile in response to nutritional and …

The concept of 'lifestyle 'includes different factors such as nutrition, behavior, stress, physical
activity, working habits, smoking and alcohol consumption. Increasing evidence shows that …

Folate receptors (FRα, FRβ and FRγ) are cysteine-rich cell-surface glycoproteins that bind
folate with high affinity to mediate cellular uptake of folate. Although expressed at very low …

Early nutrition affects adult metabolism in humans and other mammals, potentially via
persistent alterations in DNA methylation. With viable yellow agouti (A vy) mice, which …

Folate deficiency causes massive incorporation of uracil into human DNA (4 million per cell)
and chromosome breaks. The likely mechanism is the deficient methylation of dUMP to …

Collectively, the evidence from epidemiologic, animal and human studies strongly suggests
that folate status modulates the risk of develo** cancers in selected tissues, the most …

DNA methylation influences the expression of some genes and depends upon the
availability of methyl groups from S-adenosylmethionine (SAM). Dietary methyl groups …

Folate plays a critical role in the prevention of uracil incorporation into DNA and
hypomethylation of DNA. This activity is compromised when vitamin B12 concentration is …

DNA methylation is not just for basic scientists any more. There is a growing awareness in
the medical field that having the correct pattern of genomic methylation is essential for …

Folate, a water-soluble B vitamin, has recently garnered much attention because of its
purported role in the pathogenesis of cardiovascular disease, 1–4 neural tube defects, 5–7 …