Alzheimer's disease (AD) is characterized by the development of amyloid plaques and
neurofibrillary tangles (NFTs) consisting of aggregated β-amyloid (Aβ) and tau, respectively …

Diabetes mellitus (DM) is a common disease worldwide. There is a strong association
between DM and neurovascular and neurodegenerative disorders. The first group mainly …

In general, proteins can only execute their various biological functions when they are
appropriately folded. Their amino acid sequence encodes the relevant information required …

The molecular mechanisms by which different proteins assemble into highly ordered fibrillar
deposits and cause disease remain topics of debate. Human amylin (also known as islet …

Since the successful conquest of many acute, communicable (infectious) diseases through
the use of vaccines and antibiotics, the currently most prevalent diseases are chronic and …

Abstract Type 2 diabetes (T2D) is now understood to be a complex disorder that involves
multiple organ systems. However, in the early 1900s, scientists believed diabetes to be a …

TP53 is commonly altered in human cancer, and Tp53 reactivation suppresses tumours in
vivo in mice,(TP53 and Tp53 are also known as p53). This strategy has proven difficult to …

Human islet amyloid polypeptide (hIAPP, or amylin) forms amyloid deposits in the islets of
Langerhans, a phenomenon that is associated with type‐2 diabetes impacting millions of …

Incretin‐based therapies, the most recent therapeutic options for type 2 diabetes mellitus
(T2DM) management, can modify various elements of the disease, including hypersecretion …

Amylin, a pancreatic peptide, and amyloid-beta peptides (Aβ), a major component of
Alzheimer's disease (AD) brain, share similar β-sheet secondary structures, but it is not …