Significant recent progress in understanding rheumatoid arthritis (RA) pathogenesis has led
to improved treatment and quality of life. The introduction of targeted-biologic and-synthetic …

Rheumatoid arthritis (RA) is a chronic prototypic immune-mediated inflammatory disease
which is characterized by persistent synovial inflammation, leading to progressive joint …

Purpose: Recent advances in immunotherapy highlight the antitumor effects of immune
checkpoint inhibition despite a relatively limited subset of patients receiving clinical benefit …

Histone deacetylase (HDAC) inhibitors are powerful epigenetic regulators that have
enormous therapeutic potential and have pleiotropic effects at the cellular and systemic …

Despite considerable research efforts, inflammatory diseases remain a heavy burden on
human health, causing significant economic losses annually. Histone deacetylases …

Objectives Non-selective histone deacetylase (HDAC) inhibitors (HDACi) have
demonstrated anti-inflammatory properties in both in vitro and in vivo models of rheumatoid …

Immune-mediated diseases are clinically heterogeneous but they share genetic and
pathogenic mechanisms. These diseases may develop from the interplay of genetic factors …

B cells have a critical role in the initiation and acceleration of autoimmune diseases,
especially those mediated by autoantibodies. In the peripheral lymphoid system, mature B …

Aim This study investigated the role of Lactobacillus rhamnosus GG (LGG) on bone loss and
local and systemic inflammation in an in vivo mouse model of experimental periodontitis …

Rheumatoid arthritis (RA) is a complex autoimmune inflammatory rheumatic disease
characterized by an imbalance between immunological reactivity and immune tolerance …